Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1 - quartile 3) tau-A (ng/ml) values were 58 (43-71) versus 51 (43-67), 72 (57-84) versus 71 (59-82) and 76 (61-92) versus 75 (64-89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively (pgroup = 0.95). Median tau C (ng/ml) values were 38 (29-50) versus 36 (29-49), 49 (38-58) versus 48 (33-59) and 48 (39-59) versus 48 (36-62) (pgroup = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA.

中文翻译：

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院外心脏骤停后，血清tau片段可预测死亡或不良神经系统预后。

背景：缺氧性脑损伤是因院外心脏骤停（OHCA）复苏后死亡的主要原因，预后具有挑战性。这项研究的目的是评估tau的两个片段作为血清神经生物学预后标志物的潜力。方法：纳入目标温度管理（TTM）试验中的171例患者的单中心子研究，在OHCA后24小时内随机分配到33°C的TTM或36°C的TTM。在OHCA后24、48和72小时，在血清中测量神经元蛋白tau的片段（tau-A和tau-C）。主要终点是神经系统预后。结果：tau-A（ng / ml）的中位数（四分位数1-四分位数）分别为58（43-71），51（43-67），72（57-84），71（59-82）和76（ 61-92）与75（64-89）分别在24、48和72 h时获得了良好与不利的结果（pgroup = 0。95）。tau C中位值（ng / ml）为38（29-50）对36（29-49），49（38-58）对48（33-59）和48（39-59）对48（36-62） ）（pgroup = 0.95）。Tau-A和tau-C不能预测神经系统的预后（48小时在接受者操作曲线下的面积； tau-A：0.51和tau-C：0.51）。结论：OHCA后，tau片段的血清水平无法预测神经系统的预后。