Thymosin Beta-4 (Tβ4) is known as a major pleiotropic actin-sequestering protein that is involved in tumorigenesis. Tβ4 is a water-soluble protein that has different promising clinical applications in the remodeling and ulcerated tissues repair following myocardial infarction, stroke, plasticity and neurovascular remodeling of the Peripheral Nervous System (PNS) and the Central Nervous System (CNS). On the other hand, similar effects have been observed for Tβ4 in other kinds of tissues, including cardiac muscle tissue. In recent reports, as it activates resident epicardial progenitor cells and modulates inflammatory-caused injuries, Tβ4 has been suggested as a promoter of the survival of cardiomyocytes. Furthermore, Tβ4 may act in skeletal muscle and different organs in association/synergism with numerous other tissue repair stimulating factors, including melatonin and C-fiber-derived peptides. For these reasons, the present review highlights the promising role of Tβ4 in cardiac healing.

胸腺素Beta-4（Tβ4）被称为参与肿瘤发生的主要多效肌动蛋白替代蛋白。Tβ4是一种水溶性蛋白，在心肌梗塞，中风，可塑性和周围神经系统（PNS）和中枢神经系统（CNS）的神经血管重塑后的重塑和溃疡组织修复中具有不同的临床应用前景。另一方面，已经在包括心肌组织的其他种类的组织中观察到对Tβ4的类似作用。在最近的报道中，由于它激活驻留的心外膜祖细胞并调节由炎症引起的损伤，所以已经提出了Tβ4作为心肌细胞存活的促进剂。此外，Tβ4可能与许多其他组织修复刺激因子相关联/协同作用于骨骼肌和不同器官，包括褪黑激素和C纤维衍生的肽。由于这些原因，本综述强调了Tβ4在心脏愈合中的有希望的作用。