HIV infection is associated with a rapid and sustained inversion of the Vδ1:Vδ2 T-cell ratio in peripheral blood. Studies of antiretroviral therapy (ART)-treated cohorts suggest that ART is insufficient to reconstitute either the frequency or function of the γδ T-cell subset. Recent advances are now beginning to shed light on the relationship between microbial translocation, chronic inflammation, immune ageing and γδ T-cell immunology. Here, we review the impact of acute, chronic untreated and treated HIV infection on circulating and mucosal γδ T-cell subsets and highlight novel approaches to harness γδ T cells as components of anti-HIV immunotherapy.

中文翻译：

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HIV感染和抗逆转录病毒疗法期间的γδT细胞反应。

HIV感染与外周血中Vδ1：Vδ2T细胞比值快速持续转化有关。抗逆转录病毒疗法（ART）治疗的队列研究表明，ART不足以重构γδT细胞亚群的频率或功能。现在，有关微生物易位，慢性炎症，免疫衰老和γδT细胞免疫学之间关系的最新进展开始得到阐明。在这里，我们回顾了急性，慢性未经治疗和已治疗的HIV感染对循环和粘膜γδT细胞亚群的影响，并重点介绍了利用γδT细胞作为抗HIV免疫治疗成分的新方法。