Fibroblast growth factors (FGF) constitute a large family of proteins with pleiotropic effects on development, organogenesis, and metabolism. The FGF19 subclass includes growth factors circulating with the blood referred to as endocrine FGF. Representatives of the FGF19 subclass, including FGF19, FGF21, and FGF23, act via FGFR receptors. The proteins of FGF19 subfamily influence the enterohepatic circulation of bile, participate in glucose and lipid metabolism regulation, and maintenance of phosphorus and vitamin D3 homeostasis. FGF19 and FGF21 are activated under different physiological and pathological conditions.

中文翻译：

---

FGF19 亚家族成员：FGF19 和 FGF21。


成纤维细胞生长因子 (FGF) 是一个对发育、器官发生和代谢具有多效性作用的蛋白质大家族。 FGF19 亚类包括随血液循环的生长因子，称为内分泌 FGF。 FGF19 亚类的代表，包括 FGF19、FGF21 和 FGF23，通过 FGFR 受体发挥作用。 FGF19亚家族蛋白影响胆汁的肠肝循环，参与糖脂代谢调节，以及维持磷和维生素D3稳态。 FGF19和FGF21在不同的生理和病理条件下被激活。