Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six 18F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvania using the AllinOne synthesis module. The development of automated syntheses with varying complexity was accomplished including HPLC purification, SPE procedures and final formulation with sterile filtration. The six radiopharmaceuticals were obtained in high yield and high specific activity with full automation on the AllinOne synthesis module under current good manufacturing practice (cGMP) guidelines. The study demonstrates the versatility of this synthesis module for the preparation of a wide variety of 18F-labeled radiopharmaceuticals for PET imaging studies.

中文翻译：

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在 AllinOne 上自动合成六种不同的 18F 标记的放射性示踪剂。

将正电子发射断层扫描 (PET) 快速应用到临床和临床前研究中，需要以安全和可重复的方式制备 PET 放射性药物的自动化合成。本研究的目的是为宾夕法尼亚大学使用 AllinOne 合成模块常规生产的这六种 18F 标记的放射性药物开发自动化合成方法。完成了具有不同复杂性的自动化合成的开发，包括 HPLC 纯化、SPE 程序和无菌过滤的最终配方。根据当前的良好生产规范 (cGMP) 指南，在 AllinOne 合成模块上完全自动化地获得了高产率和高比活度的六种放射性药物。