ABSTRACT Molecular recognition in water is challenging but water-soluble molecularly imprinted nanoparticle (MINP) receptors were produced readily by double cross-linking of surfactant micelles in the presence of suitable template molecules. When the micellar surface was decorated with different polyhydroxylated ligands, significant interactions could be introduced between the surface ligands and the template. Flexible surface ligands worked better than rigid ones to interact with the polar moiety of the template, especially for those template molecules whose water-exposed surface is not properly solvated by water. The importance of these hydrophilic interactions was examined in the context of different substrates, density of the surface ligands, and surface-cross-linking density of the MINP. Together with the hydrophobic interactions in the core, the surface hydrophilic interactions can be used to enhance the binding of guest molecules in water. GRAPHICAL ABSTRACT

中文翻译：

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分子印迹交联胶束印迹和结合中的表面配体

摘要 水中的分子识别具有挑战性，但在合适的模板分子存在下，通过表面活性剂胶束的双交联很容易产生水溶性分子印迹纳米颗粒 (MINP) 受体。当胶束表面用不同的多羟基化配体装饰时，表面配体和模板之间会引入显着的相互作用。柔性表面配体比刚性配体更能与模板的极性部分相互作用，特别是对于那些暴露于水的表面没有被水适当溶剂化的模板分子。在不同的底物、表面配体的密度和 MINP 的表面交联密度的背景下检查了这些亲水相互作用的重要性。连同核心中的疏水相互作用，表面亲水相互作用可用于增强客体分子在水中的结合。图形概要