Cells must dynamically adapt to altered environmental conditions, particularly during times of stress, to ensure their ability to function effectively and survive. The macroautophagy/autophagy pathway is highly conserved across eukaryotic cells and promotes cell survival during stressful conditions. In general, basal autophagy occurs at a low level to sustain cellular homeostasis and metabolism. However, autophagy is robustly upregulated in response to nutrient deprivation, pathogen infection and increased accumulation of potentially toxic protein aggregates and superfluous organelles. Within the cell, RNA decay maintains quality control to remove aberrant transcripts and regulate appropriate levels of gene expression. Recent evidence has identified components of the cellular mRNA decay machinery as novel regulators of autophagy. Here, we review current findings that demonstrate how autophagy is modulated through RNA decay. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability.

中文翻译：

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降解的边缘：RNA衰减的自噬调节。

细胞必须动态适应变化的环境条件，尤其是在压力时期，以确保其有效发挥功能并存活的能力。巨自噬/自噬途径在真核细胞中高度保守，并在压力条件下促进细胞存活。通常，基础自噬发生在较低水平，以维持细胞稳态和新陈代谢。然而，自噬被强烈地上调，以响应营养缺乏，病原体感染以及潜在毒性蛋白聚集体和多余细胞器积累的增加。在细胞内，RNA衰减可维持质量控制，以去除异常的转录本并调节基因表达的适当水平。最近的证据已经确定了细胞mRNA衰变机制的成分是自噬的新型调节剂。这里，我们回顾了当前的发现，这些发现证明了如何通过RNA衰减调节自噬。本文归类于：RNA周转和监视>周转/监视机制RNA周转和监视> RNA稳定性的调节。