BACKGROUND Chronic inflammation and impaired sleep increase the risk for cardiovascular disease. Menopausal women may be particularly at risk as a result of impaired sleep. The objective of the current investigation was to assess the relationship between poor sleep and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) in healthy non- and postmenopausal women and men. METHODS A fasting blood draw was obtained from 122 healthy men and women (31 were postmenopausal). Higher scores on the Pittsburgh Sleep Quality Index (PSQI) were used to define poor sleep. Given the sample size and healthy nature of the sample, hierarchical linear regression analyses were performed on a composite inflammatory score involving CRP, IL-6, and TNF-α. Sex/menopausal group and PSQI were entered as predictors, and the interaction of the group by PSQI was entered stepwise. Analyses on MPO were performed separately. RESULTS Sleep quality was associated with higher inflammatory activity (β = 0.272, P = 0.003), which remained significant (P = 0.046) after controlling for age, waist circumference, exercise times per week, and depressive symptoms. While in the same direction, sleep quality was not significantly associated with MPO. Dichotomizing sleep quality led to similar results. CONCLUSION Impaired sleep quality is independently associated with greater inflammation in healthy adult men and women. Despite an overall less favorable metabolic and inflammatory profile in postmenopausal women, impaired sleep did not emerge as differentially related to inflammatory activity in this group.

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睡眠质量受损与炎症标志物同时升高有关：绝经后妇女的风险更大吗？

背景技术慢性炎症和睡眠障碍增加了患心血管疾病的风险。睡眠障碍可能会使更年期妇女处于特别危险的境地。当前研究的目的是评估健康人中睡眠不足与C反应蛋白（CRP），白细胞介素6（IL-6），肿瘤坏死因子α（TNF-α）和髓过氧化物酶（MPO）之间的关系。 -和绝经后的男女。方法从122名健康的男性和女性（31名绝经后）中抽取空腹抽血。匹兹堡睡眠质量指数（PSQI）的较高分数用于定义不良睡眠。给定样本量和样本的健康性质，对涉及CRP，IL-6和TNF-α的复合炎症评分进行分层线性回归分析。性别/更年期组和PSQI作为预测指标，然后逐步输入PSQI进行的小组互动。对MPO的分析是分别进行的。结果睡眠质量与较高的炎症活动相关（β= 0.272，P = 0.003），在控制年龄，腰围，每周运动时间和抑郁症状后，炎症活动仍然很明显（P = 0.046）。在相同的方向上，睡眠质量与MPO无关。将睡眠质量二分法得到了相似的结果。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后妇女的总体代谢和炎症状况较差，但该组中并未出现睡眠障碍与炎症活动相关的差异。分别对MPO进行分析。结果睡眠质量与较高的炎症活动相关（β= 0.272，P = 0.003），在控制年龄，腰围，每周运动时间和抑郁症状后，炎症活动仍然很明显（P = 0.046）。在相同的方向上，睡眠质量与MPO无关。将睡眠质量二分法得到了相似的结果。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后女性的总体代谢和炎症状况较差，但该组的睡眠不足并未与炎症活动相关。对MPO的分析是分别进行的。结果睡眠质量与较高的炎症活动相关（β= 0.272，P = 0.003），在控制年龄，腰围，每周运动时间和抑郁症状后，炎症活动仍然很明显（P = 0.046）。在相同的方向上，睡眠质量与MPO无关。将睡眠质量二分法得到了相似的结果。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后妇女的总体代谢和炎症状况较差，但该组中并未出现睡眠障碍与炎症活动相关的差异。在控制了年龄，腰围，每周运动时间和抑郁症状后，其仍保持显着性（P = 0.046）。在相同的方向上，睡眠质量与MPO无关。将睡眠质量二分法得到了相似的结果。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后妇女的总体代谢和炎症状况较差，但该组中并未出现睡眠障碍与炎症活动相关的差异。在控制了年龄，腰围，每周运动时间和抑郁症状后，其仍保持显着性（P = 0.046）。在相同的方向上，睡眠质量与MPO无关。将睡眠质量二分法得到了相似的结果。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后妇女的总体代谢和炎症状况较差，但该组中并未出现睡眠障碍与炎症活动相关的差异。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后妇女的总体代谢和炎症状况较差，但该组中并未出现睡眠障碍与炎症活动相关的差异。结论睡眠质量受损与健康成年男性和女性的更大炎症独立相关。尽管绝经后妇女的总体代谢和炎症状况较差，但该组中并未出现睡眠障碍与炎症活动相关的差异。