Inbreeding depression has been demonstrated to impact vital rates, productivity, and performance in human populations, wild and endangered species, and in recent years, the domestic species. In all cases, standardized, high-quality phenotype data on all individuals are invaluable for longitudinal analyses such as those required to evaluate vital rates of a study cohort. Further, many investigators agree upon the preference for and utility of genomic measures of inbreeding in lieu of pedigree-based estimates of inbreeding. We evaluated the association of measures of reproductive fitness in 93 Golden Retrievers enrolled in the Golden Retriever Lifetime Study with a genomic measurement of inbreeding, FROH. We demonstrate a statistically significant negative correlation between fecundity and FROH. This work sets the stage for larger scale analyses to investigate genomic regions associated with fecundity and other measures of fitness.

中文翻译：

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近亲沮丧导致金毛繁殖力降低。

近亲衰退已被证明会影响人口，野生和濒危物种以及近年来的家养物种的生命率，生产力和性能。在所有情况下，有关所有个体的标准化，高质量表型数据对于纵向分析（例如评估研究队列生命率所需的分析）都是无价的。此外，许多研究者都同意对近交基因组测量的偏爱和实用性，而不是基于谱系的近交估计。我们用近亲繁殖的基因组测量值FROH评估了参与“金毛猎犬生命周期研究”的93个金毛猎犬的生殖健康指标。我们证明生育力和FROH之间的统计显着负相关。