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Immunophenotypic Features of Myeloid Neoplasms Associated with Chromosome 7 Abnormalities.
Cytometry Part B: Clinical Cytometry ( IF 2.3 ) Pub Date : 2019-02-25 , DOI: 10.1002/cyto.b.21775
Xueyan Chen 1 , Brent L Wood 1, 2 , Sindhu Cherian 1
Affiliation  

BACKGROUND Abnormalities involving chromosome 7 are one of the most frequent chromosomal aberrations in myeloid neoplasms including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) and are associated with an adverse prognosis. Immunophenotyping by flow cytometry provides data that can assist in the diagnosis and classification of myeloid neoplasms. The immunophenotypic features of myeloid neoplasms with monosomy 7 or del(7q) have not been previously described in a comprehensive fashion. METHODS We retrospectively analyzed flow cytometric data of myeloid neoplasms with monosomy 7 or del(7q) and summarized associated immunophenotypic features. RESULTS Myeloid neoplasms with monosomy 7 typically demonstrate multiple immunophenotypic abnormalities on myeloid blasts and maturing myelomonocytic cells. Increased CD14 expression on maturing granulocytic cells was characteristically seen in myeloid neoplasms with monosomy 7. This abnormality was significantly more frequent in myeloid neoplasms with monosomy 7 than in those with del(7q) (92.9% vs. 8.2%, P < 0.0001). The presence of increased CD14 expression on maturing granulocytic cells could be seen in cases with monosomy 7 in the setting of a normal blast percentage and when minimal (<3) other immunophenotypic abnormalities were seen on myeloid populations. CONCLUSIONS Increased CD14 expression on maturing granulocytic cells can be helpful in identifying patients with myeloid neoplasms who have monosomy 7. © 2019 International Clinical Cytometry Society.

中文翻译:

与染色体7异常相关的骨髓肿瘤的免疫表型特征。

背景技术涉及7号染色体的异常是骨髓瘤(包括骨髓增生异常综合症(MDS)和急性髓细胞性白血病(AML))中最常见的染色体畸变之一,并与不良预后相关。通过流式细胞术进行免疫分型提供的数据可帮助诊断和分类骨髓瘤。先前尚未以全面的方式描述具有7号或7号三角染色体的骨髓肿瘤的免疫表型特征。方法我们回顾性分析了单核7或del(7q)骨髓瘤的流式细胞仪数据,并总结了相关的免疫表型特征。结果单核性7的骨髓瘤通常在骨髓母细胞和成熟的骨髓单核细胞上表现出多种免疫表型异常。在患有单胞体7的骨髓瘤中,典型地观察到成熟的粒细胞上CD14表达的增加。与患有del(7q)的骨髓瘤相比,这种异常的发生率明显更高(分别为92.9%与8.2%,P <0.0001)。在正常爆炸百分比设置的情况下,在单核细胞7病例中,以及在髓样群体中观察到极少(<3)其他免疫表型异常时,可以看到成熟的粒细胞上CD14表达增加。结论成熟的粒细胞上CD14表达增加可能有助于鉴定患有7号单体性的髓样肿瘤患者。©2019 International Clinical Cytometry Society。具有7号单体性的骨髓瘤的这种异常率显着高于具有del(7q)的髓样肿瘤(92.9%vs. 8.2%,P <0.0001)。在正常爆炸百分比设置的情况下,在单核细胞7病例中,以及在髓样群体中观察到极少(<3)其他免疫表型异常时,可以看到成熟的粒细胞上CD14表达增加。结论成熟的粒细胞上CD14表达增加可能有助于鉴定患有7号单体性的髓样肿瘤患者。©2019 International Clinical Cytometry Society。具有7号单体性的骨髓瘤的这种异常率显着高于具有del(7q)的髓样肿瘤(92.9%vs. 8.2%,P <0.0001)。在正常爆炸百分比设置的情况下,在单核细胞7病例中,以及在髓样群体中观察到极少(<3)其他免疫表型异常时,可以看到成熟的粒细胞上CD14表达增加。结论成熟的粒细胞上CD14表达增加可能有助于鉴定患有7号单体性的髓样肿瘤患者。©2019 International Clinical Cytometry Society。在正常爆炸百分比设置的情况下,在单核细胞7病例中,以及在髓样群体中观察到极少(<3)其他免疫表型异常时,可以看到成熟的粒细胞上CD14表达增加。结论成熟的粒细胞上CD14表达增加可能有助于鉴定患有7号单体性的髓样肿瘤患者。©2019 International Clinical Cytometry Society。在正常爆炸百分比设置的情况下,在单核细胞7病例中,以及在髓样群体中观察到极少(<3)其他免疫表型异常时,可以看到成熟的粒细胞上CD14表达增加。结论成熟的粒细胞上CD14表达增加可能有助于鉴定患有7号单体性的髓样肿瘤患者。©2019 International Clinical Cytometry Society。
更新日期:2019-11-01
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