Thermal treatment of short‐chain oligopeptides is able to initiate the process of their self‐assembly with the formation of organic nanostructures with unique properties. On the other hand, heating can lead to a chemical reaction with the formation of new substances with specific properties and ability to form structures with different morphology. Therefore, in order to have a desired process, researcher needs to find its temperature range. In the present work, cyclization of _L‐isoleucyl‐_L‐alanine dipeptide in the solid state upon heating was studied. Kinetic parameters of this reaction were estimated within the approaches of the nonisothermal kinetics. The correlation between side chain structure of dipeptides and temperature of their cyclization in the solid state was found for the first time. This correlation may be used to predict the temperature, at which dipeptide self‐assembly changes to chemical reaction. The differences in self‐assembly of linear and cyclic dipeptides were demonstrated using atomic force microscopy. The effect of dipeptide concentration in a source solution and an organic solvent used on self‐assembly of dipeptides was shown. The new information obtained on the thermal properties and self‐assembly of linear and cyclic forms of _L‐isoleucyl‐_L‐alanine may be useful for the design of new nanomaterials based on oligopeptides, as well as for the synthesis of cyclic oligopeptides.

中文翻译：

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固态L-异亮氨酰-L-丙氨酸的热诱导环化：二肽结构对反应温度和自组装的影响。

短链寡肽的热处理能够通过形成具有独特性质的有机纳米结构来启动其自组装过程。另一方面，加热会导致化学反应，形成具有特定性质并能够形成具有不同形态的结构的新物质。因此，为了具有所需的过程，研究人员需要找到其温度范围。在当前的工作中，_L-异亮_氨酰_-L的环化研究了加热后固态的丙氨酸二肽。该反应的动力学参数是在非等温动力学方法范围内估算的。首次发现了二肽的侧链结构与固态环化温度之间的相关性。这种相关性可以用来预测温度，在该温度下二肽自组装改变为化学反应。使用原子力显微镜证实了线性和环状二肽自组装的差异。显示了源溶液和有机溶剂中二肽浓度对二肽自组装的影响。获得有关_L-异亮_氨酰_-L的线性和循环形式的热性质和自组装的新信息丙氨酸可用于设计基于寡肽的新型纳米材料，以及用于合成环状寡肽。