Absence of sarcoplasmic MxA expression in antisynthetase syndrome in cohort of 194 cases,Neuropathology and Applied Neurobiology

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Absence of sarcoplasmic MxA expression in antisynthetase syndrome in cohort of 194 cases
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2019-05-29 , DOI: 10.1111/nan.12551
M Inoue _{1,

2} , J Tanboon _{1,

2} , M Okubo _{1,

2} , K Theerawat _{1,

2} , Y Saito _{1,

2} , M Ogasawara _{1,

2} , L A Indrawati _{1,

2} , A Uruha ₃ , N Okiyama ₄ , M Fujimoto ₅ , S Suzuki ₆ , I Nishino _{1,

2}

Affiliation

We have read with great interest the recent article entitled 'Diagnostic potential of sarcoplasmic MxA expression in subsets of dermatomyositis' by Uruha et al. [1]. The authors validated the diagnostic utility of myxovirus resistance protein A (MxA) expression in myofibers in dermatomyositis (DM) as compared with other diagnostic markers regardless of subsets, following the first report for MxA as a diagnostic marker of DM [2]. In the paper, we were particularly intrigued by the question of whether antisynthetase syndrome (ASS) -associated myositis is a pathologically distinct from DM. They reported that none of 30 cases with ASS had MxA expression on myofibers. This article is protected by copyright. All rights reserved.

中文翻译：

194例抗合成酶综合征中肌浆MxA表达缺失

我们非常感兴趣地阅读了 Uruha 等人最近发表的题为“皮肌炎亚组中肌浆 MxA 表达的诊断潜力”的文章。[1]。在首次报道 MxA 作为 DM 的诊断标志物之后，作者验证了与其他诊断标志物相比，黏液病毒抗性蛋白 A (MxA) 在皮肌炎 (DM) 中的肌纤维表达的诊断效用 [2]。在这篇论文中，我们对抗合成酶综合征 (ASS) 相关性肌炎在病理上是否与 DM 不同这一问题特别感兴趣。他们报告说，30 例 ASS 患者中没有一个在肌纤维上有 MxA 表达。本文受版权保护。版权所有。

更新日期：2019-05-29

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