Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup ( ATRT ‐ TYR ),Neuropathology and Applied Neurobiology

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Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup ( ATRT ‐ TYR )
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2019-07-17 , DOI: 10.1111/nan.12560
M Hasselblatt ₁ , C Thomas ₁ , K Nemes ₂ , C-M Monoranu ₃ , M J Riemenschneider ₄ , A Koch ₅ , D Sumerauer ₆ , P Hauser ₇ , W Paulus ₁ , P D Johann _{8,

9,

10} , M Kool _{8,

9,

10} , M C Frühwald ₂

Affiliation

Institute of Neuropathology, University Hospital Münster, Münster, Germany.
Swabian Childrens' Cancer Center, University Childrens' Hospital Augsburg and EU-RHAB Registry, Augsburg, Germany.
Department of Neuropathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany.
Department of Neuropathology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Department of Pediatric Hematology and Oncology, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.
2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.

Atypical teratoid/rhabdoid tumour (ATRT) is a malignant brain tumour mainly occurring in young children [1]. Mutations of chromatin remodelling complex member SMARCB1/INI1 or (rarely) SMARCA4/BRG1 are the sole recurrent genetic lesions [2, 3]. On an epigenetic level, however, ATRT is a heterogeneous disease comprised of three different molecular subgroups (ATRT-TYR, ATRT-SHH and ATRT-MYC). This article is protected by copyright. All rights reserved.

中文翻译：

酪氨酸酶免疫组化可用于诊断酪氨酸酶亚组（ATRT-TYR）的非典型畸胎瘤/横纹肌瘤

非典型畸胎瘤/横纹肌样瘤(ATRT)是一种主要发生于幼儿的恶性脑肿瘤[1]。染色质重塑复合体成员 SMARCB1/INI1 或（很少）SMARCA4/BRG1 的突变是唯一的复发性遗传病变 [2, 3]。然而，在表观遗传水平上，ATRT 是一种异质性疾病，由三个不同的分子亚群（ATRT-TYR、ATRT-SHH 和 ATRT-MYC）组成。本文受版权保护。版权所有。

更新日期：2019-07-17

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