Next-day residual effects are a common problem with current hypnotics. The purpose of the present study was to evaluate the residual effects of eszopiclone on the physical and cognitive functions of healthy elderly people in the early morning and the day following drug administration. Four men and six women aged 63–72 years were administered eszopiclone 1 mg or placebo in a randomized, double-blind and crossover design. Measures of objective parameters and subjective ratings were obtained at 4:00, 6:00, and every 2 h from 6:00 to 16:00 hours. For the timed up-and-go test, the main effects of time were seen. For the critical flicker fusion, eszopiclone had significantly worse results compared to placebo in early morning (4:00). There were no significant differences between eszopiclone and placebo in other objective assessments. For the sleep latency, eszopiclone had significantly shorter results compared to placebo (eszopiclone vs placebo = 28.4 vs 52.5 min, p = 0.047). Feeling of deep sleep and the number of wake after sleep onset did not show any significant differences between eszopiclone and placebo. Based on the above results, the changes of physical and cognitive functions in the healthy elderly after taking hypnotics, it was found that eszopiclone 1 mg is likely to be unharmful for the healthy elderly. Further studies of elderly insomniacs with midnight awakenings are needed.

中文翻译：

---

右佐匹克隆和安慰剂对健康老年受试者的残留影响：一项随机双盲研究

次日残留效应是当前催眠药的常见问题。本研究的目的是评估右佐匹克隆对健康老年人在清晨和给药后第二天的身体和认知功能的残留影响。在随机、双盲和交叉设计中，4 名 63-72 岁男性和 6 名女性服用右佐匹克隆 1 mg 或安慰剂。在 4:00、6:00 和从 6:00 到 16:00 时每 2 小时测量客观参数和主观评分。对于定时启动测试，观察到了时间的主要影响。对于临界闪烁融合，与安慰剂相比，右佐匹克隆在清晨（4:00）的结果明显更差。在其他客观评估中，右佐匹克隆和安慰剂之间没有显着差异。对于睡眠潜伏期，与安慰剂相比，右佐匹克隆的结果明显更短（右佐匹克隆 vs 安慰剂 = 28.4 vs 52.5 分钟，p = 0.047）。右佐匹克隆和安慰剂之间的深度睡眠感觉和入睡后醒来的次数没有显示任何显着差异。根据以上结果，健康老年人服用安眠药后身体和认知功能的变化，发现右佐匹克隆1mg对健康老年人可能无害。需要对午夜醒来的老年失眠症患者进行进一步研究。健康老年人服用安眠药后身体和认知功能的变化，发现右佐匹克隆1mg对健康老年人可能无害。需要对午夜醒来的老年失眠症患者进行进一步研究。健康老年人服用安眠药后身体和认知功能的变化，发现右佐匹克隆1mg对健康老年人可能无害。需要对午夜醒来的老年失眠症患者进行进一步研究。