OBJECTIVES MI Paste Plus remineralizer (Rem) strengthens dental structures after bleaching. We investigated the effect of Rem on the penetration of hydrogen peroxide (H2O2), bleaching effectiveness, and pulp inflammation after bleaching. MATERIALS AND METHODS Bovine disks were grouped as follows (n = 10): control (untreated), bleached (Ble; 35% H2O2, 30 min), Ble-Rem (H2O2 followed by Rem, 30 min), Rem-Ble (Rem followed by H2O2), Rem-Ble-Rem (Rem before and after H2O2), and Ble+Rem (mixture of Rem with H2O2, 1:1, 30 min). The penetration of H2O2 was quantified and bleaching efficacy was analyzed. Upper rat molars (n = 10) received the same treatments at random. The rats were euthanized after two days and 30 days, and their jaws were removed for histological analysis. Statistical tests were performed (P < 0.05). RESULTS The bleached groups, except Ble+Rem (P > 0.05), showed significant H2O2 penetration compared with control (P < 0.05). Color alteration analysis showed that ΔL and ΔE were significantly higher in the bleached groups than those in control (P < 0.05); the Δb of the bleached groups differed from that of control at 24 h (P < 0.05). At two days, necrosis or inflammation was observed in the bleached groups compared with control (P < 0.05), except Ble+Rem, which was similar to control (P > 0.05). At 30 days, tertiary dentin formation was significant in the bleached groups (P < 0.05), except Ble+Rem (P > 0.05). CONCLUSION The mixture of MI Paste Plus and bleaching gel reduces H2O2 penetration and pulp damage and maintains bleaching effectiveness. CLINICAL RELEVANCE Because bleaching can damage dental tissues, we studied a new bleaching protocol that reduces damage to the pulp tissue while maintaining bleaching efficiency: a single application of 30 min of MI Paste Plus mixed with 35% H2O2 bleaching gel (1:1).

中文翻译：

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与MI Paste Plus混合的漂白凝胶可减少H2O2的渗透和对纸浆组织的损害，并保持漂白效果。

目的MI Paste Plus矿化剂（Rem）在漂白后可增强牙齿结构。我们研究了Rem对过氧化氢（H2O2）的渗透，漂白效果和漂白后纸浆发炎的影响。材料与方法牛盘的分组如下（n = 10）：对照（未处理），漂白（Ble； 35％H2O2，30分钟），Ble-Rem（H2O2，接着是Rem，30分钟），Rem-Ble（Rem）然后是H2O2），Rem-Ble-Rem（H2O2之前和之后的Rem）和Ble + Rem（Rem与H2O2的混合物，1：1，30分钟）。定量H 2 O 2的渗透并分析漂白效果。大鼠上磨牙（n = 10）随机接受相同的治疗。在两天和30天后对大鼠实施安乐死，并取下颌进行组织学分析。进行统计检验（P <0.05）。结果漂白组，除了Ble + Rem（P> 0.05）外，与对照组相比，H2O2渗透性显着（P <0.05）。颜色变化分析表明，漂白组的ΔL和ΔE显着高于对照组（P <0.05）。漂白组的Δb与24小时对照组的差异不显着（P <0.05）。在第2天，与对照组相比，在漂白组中观察到了坏死或炎症（P <0.05），除了Ble + Rem，与对照组相似（P> 0.05）。在30天时，除Ble + Rem（P> 0.05）外，在漂白组中第三牙本质的形成显着（P <0.05）。结论MI Paste Plus和漂白凝胶的混合物可减少H2O2渗透和纸浆损伤，并保持漂白效果。临床意义因为漂白会损害牙齿组织，