The involvement of the biliary tract in the pathophysiology of liver diseases and the increased attention paid to bile ducts in the bioconstruction of liver tissue for regenerative therapy have fueled intense research into the fundamental mechanisms of biliary development. Here, I review the molecular, cellular and tissular mechanisms driving differentiation and morphogenesis of the intrahepatic and extrahepatic bile ducts. This review focuses on the dynamics of the transcriptional and signaling modules that promote biliary development in human and mouse liver and discusses studies in which the use of zebrafish uncovered unexplored processes in mammalian biliary development. The review concludes by providing a framework for interpreting the mechanisms that may help us understand the origin of congenital biliary diseases.

中文翻译：

---

肝内和肝外胆道的发展：了解先天性疾病的框架。

胆道参与肝病的病理生理学以及越来越多地关注胆管在肝组织的生物组织中进行再生治疗，这促使人们对胆道发育的基本机制进行了深入研究。在这里，我回顾了驱动肝内和肝外胆管分化和形态发生的分子，细胞和组织结构。这篇评论集中在促进人类和小鼠肝脏中胆汁发育的转录和信号传导模块的动力学上，并讨论了斑马鱼的使用揭示了哺乳动物胆汁发育中未探索的过程的研究。回顾通过提供一个解释可能有助于我们了解先天性胆源性疾病起源的机制的框架而结束。