Uric acid (UA), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. However, an abnormal UA concentration may be connected with many diseases: a higher UA concentration, comings from improper lifestyle such as purine excessive intake and excessive drinking, may reveal hyperuricemia, gout and some cardiovascular diseases; meanwhile, some genetic diseases can result in a low level UA relatively for a long time. Therefore, to develop a rapid and accurate detection method of UA is urgent and important. Recently many detection methods have been developed to measure the level of UA in human serum and urine sample even saliva and nails and tears. This review outlines the importance of UA detection and the history of the development of UA detection methods. UA detection include spectral (ultraviolet absorption, fluorescence), electrochemical (voltammetry, electrochemiluminescence, surface plasmon resonance), chromatography (liquid and gas phase), capillary electrophoresis and isotope dilution mass spectrometry, etc. Most of the above detection methods contain both enzymatic and nonenzymatic strategies. The materials used in mentioned methods above tend to be diversified, hence an overview of materials used in UA detection are also reported.

尿酸（UA）是氧自由基的清除剂，是一种非常重要的抗氧化剂，有助于维持血压和抗氧化应激的稳定性。然而，异常的UA浓度可能与许多疾病有关：较高的UA浓度来自不适当的生活方式，例如嘌呤过量摄入和过量饮酒，可能显示高尿酸血症，痛风和一些心血管疾病；同时，某些遗传病会导致相对较低的UA水平。因此，开发一种快速准确的UA检测方法显得尤为重要和重要。最近，已开发出许多检测方法来测量人血清和尿液样本中唾液，指甲和眼泪中的UA水平。这篇综述概述了UA检测的重要性以及UA检测方法的发展历史。UA检测包括光谱（紫外吸收，荧光），电化学（伏安法，电化学发光，表面等离振子共振），色谱法（液相和气相），毛细管电泳和同位素稀释质谱法等。上述大多数检测方法同时包含酶法和酶法。非酶策略。上面提到的方法中使用的材料趋于多样化，因此也报告了UA检测中使用的材料的概述。