Parkinson's disease (PD) is a neurodegenerative movement disorder involving the selective loss of dopamine-producing neurons in the substantia nigra (SN). Differences in disease presentation, prevalence, and age of onset have been reported between males and females with PD. The content and composition of the major glycosphingolipids, phospholipids, and cholesterol were evaluated in the SN from 12 PD subjects and in 18 age-matched, neurologically normal controls. Total SN ganglioside sialic acid content and water content (%) were significantly lower in the male PD subjects than in the male controls. The content of all major gangliosides were reduced in the male PD subjects to some degree, but the neuronal-enriched gangliosides, GD1a and GT1b, were most significantly reduced. The distribution of phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositol was also significantly lower in the male PD subjects than in the male controls. However, the distribution of myelin-enriched cerebrosides and sulfatides was significantly higher in the male PD subjects than in the male controls suggesting myelin sparing in the male PD subjects. No elevation was detected for astrocytosis-linked GD3. These neurochemical changes provide evidence of selective neuronal loss in SN of the males with PD without robust astrocytosis. In contrast to the SN lipid abnormalities found in the male PD subjects, no significant abnormalities were found in the female PD subjects for SN water content or for any major SN lipids. These data indicate sex-related differences in SN lipid abnormalities in PD.

中文翻译：

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帕金森氏病黑质血脂中与性别有关的异常。

帕金森氏病（PD）是一种神经退行性运动障碍，涉及黑质（SN）中多巴胺生成神经元的选择性丢失。据报道，患有PD的男性和女性在疾病表现，患病率和发病年龄方面存在差异。在12名PD受试者的SN和18位年龄相匹配的神经学正常对照中评估了主要糖鞘脂，磷脂和胆固醇的含量和组成。男性PD受试者的总SN神经节苷脂唾液酸含量和水含量（％）显着低于男性对照。男性PD受试者中所有主要神经节苷脂的含量都有一定程度的降低，但是神经元富集的神经节苷脂GD1a和GT1b的降低最为明显。磷脂酰乙醇胺，磷脂酰胆碱，男性PD受试者的磷脂酰肌醇也明显低于男性对照组。然而，在男性PD受试者中富含髓磷脂的脑苷和硫酸脂的分布明显高于男性对照，这表明在男性PD受试者中保留了髓磷脂。与星形细胞增多症相关的GD3未检测到升高。这些神经化学变化提供了PD男性SN中选择性神经元丢失的证据，而没有明显的星形细胞增多作用。与在男性PD受试者中发现的SN脂质异常相反，在女性PD受试者中未发现SN水含量或任何主要SN脂质的显着异常。这些数据表明PD中SN脂质异常的性别相关差异。然而，在男性PD受试者中富含髓磷脂的脑苷和硫酸脂的分布明显高于男性对照，这表明在男性PD受试者中保留了髓磷脂。与星形细胞增多症相关的GD3未检测到升高。这些神经化学变化提供了PD男性SN中选择性神经元丢失的证据，而没有明显的星形细胞增多作用。与在男性PD受试者中发现的SN脂质异常相反，在女性PD受试者中未发现SN水含量或任何主要SN脂质的显着异常。这些数据表明PD中SN脂质异常的性别相关差异。然而，在男性PD受试者中富含髓磷脂的脑苷和硫酸脂的分布明显高于男性对照，这表明在男性PD受试者中保留了髓磷脂。星形细胞增多症相关的GD3未检测到升高。这些神经化学变化提供了PD男性SN中选择性神经元丢失的证据，而没有明显的星形细胞增多作用。与在男性PD受试者中发现的SN脂质异常相反，在女性PD受试者中未发现SN水含量或任何主要SN脂质的显着异常。这些数据表明PD中SN脂质异常的性别相关差异。与星形细胞增多症相关的GD3未检测到升高。这些神经化学变化提供了PD男性SN中选择性神经元丢失的证据，而没有明显的星形细胞增多作用。与在男性PD受试者中发现的SN脂质异常相反，在女性PD受试者中未发现SN水含量或任何主要SN脂质的显着异常。这些数据表明PD中SN脂质异常的性别相关差异。与星形细胞增多症相关的GD3未检测到升高。这些神经化学变化提供了PD男性SN中选择性神经元丢失的证据，而没有明显的星形细胞增多作用。与在男性PD受试者中发现的SN脂质异常相反，在女性PD受试者中未发现SN水含量或任何主要SN脂质的显着异常。这些数据表明PD中SN脂质异常的性别相关差异。