In this work, one kind of biocompatible and all-in-one dual-modal nanoprobe, based on Au nanoparticles and NIR emissive semiconducting fluorescence polymers, was developed by the one-step solvent-mediated self-assembly method for in vivo X-ray computed tomography (CT) and fluorescence bioimaging for the first time. After preparation, a series of comprehensive evaluations were performed, and the nanoprobe exhibited smart size and modification, good compatibility, inducement of autophagy, long blood circulation, unconspicuous in vivo toxicity, and excellent fluorescence/CT imaging effects. Overall, the studies in this work assuredly indicate that the synthesized Au@FP nanoparticles as a noninvasive contrast agent is suitable for in vivo fluorescence/X-ray CT bimodality biomedical imaging and diagnosis.

中文翻译：

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Au @荧光聚合物的高度生物相容性纳米粒子作为体内双峰近红外荧光/ CT成像的新型造影剂。

在这项工作中，通过一步溶剂介导的自组装体内X射线技术开发了一种基于Au纳米粒子和NIR发射半导体荧光聚合物的生物相容的多合一双峰纳米探针。首次进行计算机断层扫描（CT）和荧光生物成像。制备后，进行了一系列综合评估，纳米探针显示出灵巧的大小和修饰，良好的相容性，自噬诱导，血液循环长，体内毒性不明显以及出色的荧光/ CT成像效果。总的来说，这项工作中的研究肯定地表明，合成的Au @ FP纳米颗粒作为一种非侵入性造影剂，适用于体内荧光/ X射线CT双峰生物医学成像和诊​​断。