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Quantitative and Visual Characteristics of Primary Central Nervous System Lymphoma on 18F-FDG-PET.
Interdisciplinary Sciences: Computational Life Sciences ( IF 3.9 ) Pub Date : 2019-07-01 , DOI: 10.1007/s12539-019-00333-y
Delin Liu 1 , Ziren Kong 1 , Yuekun Wang 1 , Wenlin Chen 1 , Yaning Wang 1 , Wanqi Chen 1 , Lei Liu 1 , Yonghong Dang 2 , Wenbin Ma 1 , Yu Wang 1 , Xin Cheng 2
Affiliation  

Primary central nervous system lymphomas (PCNSLs) are rare progressive brain tumors, whose managements are significantly different from other solid tumors, especially glioblastomas. Therefore, an early diagnosis is of great significance. 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET), which can measure the glucose metabolic rate in the brain, is an increasingly common tool for early diagnosis. Twenty-five immunocompetent patients with PCNSL were reviewed in this study to describe the general characteristics of PCNSL patients' 18F-FDG-PET scans. Quantitative features included a radically enhanced maximum standardized uptake value (SUVmax) with a mean value of 23.8 ± 7.9 and a 5.8 ± 1.8 mean ratio of tumor-to-normal contralateral cortex activity (T/N). Visual characteristics, such as favored locations in the brain, lesion numbers, tumor shape, metabolic inhibition, and structural shift were determined as well. PCNSL was found to favor the cortex, especially the frontal lobe, followed by the basal ganglia and corpus callosum. All PCNSLs were near the lateral ventricular area. Tumor shapes were subdivided into three groups: diffuse, round, and irregular patterns. Reduced radiation was observed in the ipsilateral cortex, the basal ganglia and the contralateral cerebellum. The lateral ventricles were prone to be compressed on the side ipsilateral to the tumor, pushing the midline towards the contralateral side of the brain. In conclusion, aside from SUVmax and T/N values, other visual characteristics are also available to facilitate the differentiation of PCNSLs from other brain conditions on 18F-FDG-PET scans.

中文翻译:

18F-FDG-PET上原发性中枢神经系统淋巴瘤的定量和视觉特征。

原发性中枢神经系统淋巴瘤(PCNSL)是罕见的进行性脑肿瘤,其治疗与其他实体瘤(尤其是胶质母细胞瘤)有显着差异。因此,早期诊断具有重要意义。18F-氟脱氧葡萄糖(FDG)-正电子发射断层扫描(PET)可以测量大脑中的葡萄糖代谢率,是一种越来越常见的早期诊断工具。本研究回顾了25位具有免疫功能的PCNSL患者,以描述PCNSL患者18F-FDG-PET扫描的一般特征。定量特征包括从根​​本上提高的最大标准化摄取值(SUVmax),平均值为23.8±7.9,平均肿瘤与正常对侧皮层活动度(T / N)的平均值为5.8±1.8。视觉特征,例如大脑中偏爱的位置,还确定了病变数,肿瘤形状,代谢抑制和结构改变。发现PCNSL有利于皮质,尤其是额叶,其次是基底神经节和体。所有PCNSL均位于心室外侧区域附近。肿瘤形状可分为三类:弥散型,圆形和不规则型。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。以及结构转变也被确定。发现PCNSL有利于皮质,尤其是额叶,其次是基底神经节和体。所有PCNSL均位于心室外侧区域附近。肿瘤形状可分为三类:弥散型,圆形和不规则型。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。以及结构转变也被确定。发现PCNSL有利于皮质,尤其是额叶,其次是基底神经节和体。所有PCNSL均位于心室外侧区域附近。肿瘤形状可分为三类:弥散型,圆形和不规则型。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。其次是基底神经节和体。所有PCNSL均位于心室外侧区域附近。肿瘤形状可分为三类:弥散型,圆形和不规则型。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。其次是基底神经节和体。所有PCNSL均位于心室外侧区域附近。肿瘤形状可分为三类:弥散型,圆形和不规则型。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。在同侧皮质,基底神经节和对侧小脑中观察到放射线减少。侧脑室倾向于在肿瘤同侧受压,将中线推向大脑的对侧。总之,除了SUVmax和T / N值外,在18F-FDG-PET扫描中,其他视觉特征也可用于促进PCNSL与其他脑部疾病的区分。
更新日期:2019-11-01
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