AIM Our aim was to examine existing literature, and determine if there are outcome differences between accelerated corneal collagen cross-linking (A-CXL) and conventional corneal collagen cross-linking (C-CXL). METHODS A systematic review of the literature was conducted examining studies which compared A-CXL to C-CXL. Available studies were combined and the weighted mean difference (WMD) was calculated for range of outcome measures including maximal keratometry (Kmax), mean keratometry (Kmean) and minimum keratometry (Kmin), spherical equivalent, best corrected visual acuity (BCVA), and central corneal thickness (CCT). RESULTS Seven eligible studies were included in our meta-analysis, with 283 eyes (135 in A-CXLand 148 in C-CXL). In the combined analysis, there was no statistically significant difference observed in Kmin or Kmax between A-CXL and C-CXL for at least 6 months after the procedure. Kmean was statistically higher in the C-CXL group in comparison with the A-CXL group for at least 6 months after the procedure (WMD - 3.15, 95% CI - 4.34 to - 1.97, p < 0.01).No statistically significant difference observed in spherical equivalent or central corneal thickness between the A-CXL group and C-CXL group for at least 6 months after the operation. The BCVA was statistically higher in the A-CXL group in comparison with the C-CXL group for at least 6 months after the procedure (WMD - 0.05, 95% CI 0.00-0.10, p < 0.05). No surgery complication was recorded in the researches. CONCLUSION Our study demonstrated greater reductions of Kmean in the A-CXL group in comparison with the C-CXL group. Overall A-CXL is comparable to C-CXL from outcome basis.

中文翻译：

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加速与常规角膜胶原交联治疗圆锥角膜：荟萃分析和文献复习。

目的我们的目的是检查现有文献，并确定加速角膜胶原蛋白交联（A-CXL）和常规角膜胶原蛋白交联（C-CXL）之间是否存在结果差异。方法对文献进行了系统的综述，以检查将A-CXL与C-CXL进行比较的研究。合并可用的研究，并计算结果测量范围的加权平均差（WMD），包括最大角膜曲率（Kmax），平均角膜曲率（Kmean）和最小角膜曲率（Kmin），等效球镜，最佳矫正视力（BCVA）和中央角膜厚度（CCT）。结果我们的荟萃分析包括七项合格研究，共283眼（A-CXL中为135眼，C-CXL中为148眼）。在综合分析中 在手术后至少6个月内，A-CXL和C-CXL之间的Kmin或Kmax没有观察到统计学上的显着差异。术后至少6个月，C-CXL组的Kmean高于A-CXL组（WMD-3.15，95％CI-4.34至-1.97，p <0.01）。术后至少6个月内，A-CXL组和C-CXL组之间的等效球体厚度或中心角膜厚度相同。术后至少6个月，A-CXL组的BCVA高于C-CXL组（WMD-0.05，95％CI 0.00-0.10，p <0.05）。研究中未记录手术并发症。结论我们的研究表明，与C-CXL组相比，A-CXL组的Kmean降低更大。