It is not uncommon for the forensic pathologist to question whether a deceased person had experienced sepsis that could have either been the cause of or contributed to the person’s death. Often, the missing typical pathologic factors or lack of clinical and circumstantial information on the death render the autopsy of a sepsis-related death a difficult task for the forensic pathologist. Several authors emphasize on how an immunohistochemical analysis could help in diagnosing death related to sepsis. The research we carried out analyzes the main scientific studies in the literature, primarily the tracing of 21 immunohistochemical antigens evaluated to help diagnose death related to sepsis. The purpose of this review was to analyze and summarize the markers studied until now and to consider the limitations of immunohistochemistry that currently exist with regard to this particular field of forensic pathology. Immunohistochemistry provided interesting and promising results, but further studies are needed in order for them to be confirmed, so that they may be applied in standard forensic practice.

中文翻译：

---

脓毒症死后诊断中的免疫组织化学

法医病理学家通常会质疑死者是否患有败血症，而败血症可能是该人死亡的原因或促成了该人的死亡。通常，缺少典型的病理因素或缺乏关于死亡的临床和间接信息，使脓毒症相关死亡的尸检成为法医病理学家的一项艰巨任务。几位作者强调免疫组织化学分析如何有助于诊断与败血症相关的死亡。我们开展的研究分析了文献中的主要科学研究，主要是对 21 种免疫组织化学抗原的追踪评估，以帮助诊断与败血症相关的死亡。本综述的目的是分析和总结迄今为止所研究的标志物，并考虑目前在法医病理学这一特定领域中存在的免疫组织化学的局限性。免疫组织化学提供了有趣且有希望的结果，但需要进一步研究以确认它们，以便它们可以应用于标准法医实践。