Targeting inflammation in cancer has shown promise to improve and complement current therapies. The tumor microenvironment plays an important role in cancer growth and metastasis and -tumor associated macrophages possess pro-tumoral and pro-metastatic properties. Annexin A1 (ANXA1) is an immune-modulating protein with diverse functions in the immune system and in cancer. In breast cancer, high ANXA1 expression leads to poor prognosis and increased metastasis. Here, we will review ANXA1 as a modulator of inflammation, and discuss its importance in breast cancer and highlight its new role in alternative macrophage activation in the tumor microenvironment. This review may provide an updated understanding into the various roles of ANXA1 which may enable future therapeutic developments for the treatment of breast cancer.

中文翻译：

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炎症和乳腺癌中的膜联蛋白A1：肿瘤微环境的新轴。

在癌症中靶向炎症已显示出有望改善和补充目前的疗法。肿瘤微环境在癌症生长和转移中起重要作用，并且与肿瘤相关的巨噬细胞具有促肿瘤和促转移特性。Annexin A1（ANXA1）是一种免疫调节蛋白，在免疫系统和癌症中具有多种功能。在乳腺癌中，高ANXA1表达导致不良预后和增加转移。在这里，我们将回顾ANXA1作为炎症的调节剂，并讨论其在乳腺癌中的重要性，并强调其在肿瘤微环境中替代性巨噬细胞激活中的新作用。这篇综述可能对ANXA1的各种作用提供了更新的理解，这可能使将来的治疗乳腺癌发展成为可能。