AbstractSystems biology is today such a widespread discipline that it becomes difficult to propose a clear definition of what it really is. For some, it remains restricted to the genomic field. For many, it designates the integrated approach or the corpus of computational methods employed to handle the vast amount of biological or medical data and investigate the complexity of the living. Although defining systems biology might be difficult, on the other hand its purpose is clear: systems biology, with its emerging subfields systems medicine and systems pharmacology, clearly aims at making sense of complex observations/experimental and clinical datasets to improve our understanding of diseases and their treatments without putting aside the context in which they appear and develop. In this short review, we aim to specifically focus on these new subfields with the new theoretical tools and approaches that were developed in the context of cancer. Systems pharmacology and medicine now give hope for major improvements in cancer therapy, making personalized medicine closer to reality. As we will see, the current challenge is to be able to improve the clinical practice according to the paradigm shift of systems sciences.

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系统生物学、系统医学、系统药理学：什么和为什么

摘要系统生物学今天是一门如此广泛的学科，以至于很难对它的真正含义提出明确的定义。对于某些人来说，它仍然仅限于基因组领域。对于许多人来说，它指定了用于处理大量生物或医学数据并研究生活复杂性的集成方法或计算方法的语料库。尽管定义系统生物学可能很困难，但另一方面它的目的很明确：系统生物学及其新兴的子领域系统医学和系统药理学，显然旨在理解复杂的观察/实验和临床数据集，以提高我们对疾病和疾病的理解。他们的治疗没有抛开他们出现和发展的背景。在这篇简短的评论中，我们的目标是使用在癌症背景下开发的新理论工具和方法专门关注这些新的子领域。系统药理学和医学现在为癌症治疗的重大改进带来了希望，使个性化医疗更接近现实。正如我们将看到的，当前的挑战是能够根据系统科学的范式转变来改进临床实践。