Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (preexisting indwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection‐related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio [OR] 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.

中文翻译：

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脑白质营养不良儿童的可预防感染。

患有遗传性脑白质营养不良的儿童住院率很高，通常与感染有关。我们研究了潜在可改变的风险因素（预先存在的留置中心静脉通路、导尿管、硬件或机械通气；以及流感疫苗）是否与脑白质营养不良儿童的感染相关住院有关。中央静脉通路与败血症相关（优势比 [OR] 9.8）；导尿管与尿路感染有关（OR 9.0）；缺乏季节性疫苗接种与流感有关（OR 6.4）；机械通气与肺炎相关（OR 2.7）。我们得出结论，潜在的可改变风险因素与脑白质营养不良儿童的感染和住院治疗显着相关。