Annexin A2 (ANXA2) is reported to be associated with cancer development. To investigate the roles ANXA2 plays during the development of cancer, the RNAi method was used to inhibit the ANXA2 expression in caco2 (human colorectal cancer cell line) and SMMC7721 (human hepatocarcinoma cell line) cells. The results showed that when the expression of ANXA2 was efficiently inhibited, the growth and motility of both cell lines were significantly decreased, and the development of the motility relevant microstructures, such as pseudopodia, filopodia, and the polymerization of microfilaments and microtubules were obviously inhibited. The cancer cell apoptosis was enhanced without obvious significance. The possible regulating pathway in the process was also predicted and discussed. Our results suggested that ANXA2 plays important roles in maintaining the malignancy of colorectal and hepatic cancer by enhancing the cell proliferation, motility, and development of the motility associated microstructures of cancer cells based on a possible complicated signal pathway.

中文翻译：

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Annexin A2通过细胞骨架结构重排增强大肠癌和肝癌的进展。

据报道膜联蛋白A2（ANXA2）与癌症的发展有关。为了研究ANXA2在癌症发展过程中的作用，使用RNAi方法抑制caco2（人结肠直肠癌细胞系）和SMMC7721（人肝癌细胞系）细胞中ANXA2的表达。结果显示，当有效抑制ANXA2的表达时，两种细胞系的生长和运动性均显着下降，并且运动相关的微结构如假足，丝状足的发育以及微丝和微管的聚合被明显抑制。 。癌细胞凋亡增强无明显意义。还预测和讨论了该过程中可能的调节途径。