Objective: Provide evidence of HPV, C. trachomatis, and HSV infection in the oral cavity from patients with different types of stomatological lesions.

Materials and Methods: Oral swabs samples were collected from a total of 318 patients. The infectious agents were analyzed using the PCR technique. HPV genotyping and HSV type were studied using the RFLP method.

Results: We studied 137 benign lesions (B), 96 potentially malignant disorders (PMD) and 85 oral squamous cell carcinomas (OSCC). The prevalence of HPV was 34%. The most frequently genotypes detected were 6 low risk and 16 high risk. The prevalence of C. trachomatis was 16% and HSV 3%. Co-infections were detected mostly in benign lesions as following: HPV-C. trachomatis in 4%, C. trachomatis- HSV in 1.8% and HPV-HSV in 0.3%.

Conclusion: This report is the first contribution to the identification and genotype characterization of HPV in a scenario little studied in our area, and it also contributes to improving our understanding on sexually transmitted infectious agents and their associations with the oral cavity. Besides, we detect the presence of C. trachomatis and HSV and co-infection with HPV in the oral cavity, which they should be taken into account for diagnostic and treatment purposes.

目的：提供不同类型口腔病变患者口腔中HPV、沙眼衣原体和HSV感染的证据。

材料和方法：总共收集了 318 名患者的口腔拭子样本。使用PCR技术分析传染原。使用 RFLP 方法研究 HPV 基因分型和 HSV 类型。

结果：我们研究了 137 例良性病变 (B)、96 例潜在恶性疾病 (PMD) 和 85 例口腔鳞状细胞癌 (OSCC)。 HPV的患病率为34%。最常检测到的基因型是 6 种低风险基因型和 16 种高风险基因型。沙眼衣原体的患病率为 16%，HSV 的患病率为 3%。合并感染主要发生在良性病变中：HPV-沙眼衣原体占4%，沙眼衣原体-HSV占1.8%，HPV-HSV占0.3%。

结论：本报告是在我们地区很少研究的情况下对 HPV 的识别和基因型特征的第一份贡献，它也有助于提高我们对性传播感染原及其与口腔关联的了解。此外，我们还检测口腔中是否存在沙眼衣原体和HSV以及HPV的合并感染，这在诊断和治疗时应予以考虑。