BACKGROUND Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months. METHODS Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation. RESULTS Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups. CONCLUSIONS Mismatch produces sexually dimorphic post-natal growth phenotypes.

中文翻译：

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怀孕和哺乳期母狒狒（Papio sp.）饮食不匹配对产后后代早期生命表型的影响。


背景技术需要通过孕期和哺乳期饮食之间母体不匹配来进行发育规划的非人类灵长类动物模型才能转化为人类规划结果。我们展示了狒狒后代从出生到 3 岁的形态测量，以及 2 到 24 个月的血液皮质醇和促肾上腺皮质激素 (ACTH)。方法 控制母亲吃食物；不匹配的母亲在怀孕期间和哺乳期的高脂肪高能量饮食中比对照组少吃30%。结果 不匹配的母亲在怀孕期间体重减轻。出生时，两性不匹配的后代均存在体重减轻的趋势（P = 0.06）。从0-3岁开始，出现追赶性增长。不匹配的后代雄性和雌性体重增加速度快于对照组（P< 0.001）。与对照组相比，不匹配的雌性后代在 BMI (P < 0.001) 和腹围 (P = 0.008) 方面表现出更大的增加。 2 至 24 个月龄期间，两性组间的 ACTH 和皮质醇斜率相似。所有组断奶后皮质醇和促肾上腺皮质激素均增加。结论 错配会产生性别二态性的出生后生长表型。