Cytokines activation and low complement levels are common in systemic lupus erythematosus (SLE) patients. This study is aimed to explore the relationship and clinical significance of cytokines and complements with SLE activity. Serum samples of 140 SLE patients and 36 age- and gender-matched healthy controls (HC) were collected. Serum interleukin (IL)-6, IL-17, high-sensitivity C-reactive proteins (hsCRP), and complements (C3, C4) were measured in all samples. These patients were divided into 3 subgroups based on clinical disease activity with SLE Disease Activity Index 2000 (SLEDAI-2K): stationary status subgroup, mild activity subgroup, and moderate/severe activity subgroup. The serum IL-6, IL-17, and hsCRP levels in SLE patients (4.72 ± 0.28 pg/mL, 23.34 ± 1.32 pg/mL, and 4.78 ± 0.34 mg/mL) were significantly higher than those in the HC group (1.51 ± 0.05 pg/mL, 18.28 ± 1.93 pg/mL, and 1.32 ± 0.29 mg/mL), whereas C3 and C4 levels in SLE patients (0.80 ± 0.28 and 0.21 ± 0.08 g/L) were significantly lower than those in the HC group (1.49 ± 0.08 and 0.36 ± 0.02 g/L). A positive correlation was noted between the SLEDAI-2K scores and serum IL-6, IL-17, and hsCRP levels. These results support the proinflammatory cytokines and complements in the pathogenesis of SLE. The serum IL-6, IL-17, and hsCRP levels were correlated with the disease activity.

中文翻译：

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系统性红斑狼疮患者血清IL-6，IL-17和补体的变化

系统性红斑狼疮（SLE）患者常见细胞因子激活和低补体水平。这项研究旨在探讨细胞因子和补体与SLE活性的关系和临床意义。收集了140名SLE患者的血清样本以及36个年龄和性别匹配的健康对照（HC）。在所有样品中均测量了血清白介素（IL）-6，IL-17，高敏C反应蛋白（hsCRP）和补体（C3，C4）。根据临床疾病活动将这些患者根据SLE疾病活动指数2000（SLEDAI-2K）分为3个亚组：静止状态亚组，轻度活动亚组和中度/重度活动亚组。SLE患者的血清IL-6，IL-17和hsCRP水平（4.72±0.28 pg / mL，23.34±1.32 pg / mL和4.78±0。34 mg / mL）显着高于HC组（1.51±0.05 pg / mL，18.28±1.93 pg / mL和1.32±0.29 mg / mL），而SLE患者的C3和C4水平（0.80±0.28）和0.21±0.08 g / L）显着低于HC组（1.49±0.08和0.36±0.02 g / L）。SLEDAI-2K评分与血清IL-6，IL-17和hsCRP水平呈正相关。这些结果支持促炎性细胞因子和SLE发病机理中的补体。血清IL-6，IL-17和hsCRP水平与疾病活动性相关。SLEDAI-2K评分与血清IL-6，IL-17和hsCRP水平呈正相关。这些结果支持促炎性细胞因子和SLE发病机理中的补体。血清IL-6，IL-17和hsCRP水平与疾病活动性相关。SLEDAI-2K评分与血清IL-6，IL-17和hsCRP水平呈正相关。这些结果支持促炎性细胞因子和SLE发病机理中的补体。血清IL-6，IL-17和hsCRP水平与疾病活动性相关。