The importance of the microbiome to human health is increasingly recognized and has become a major focus of recent research. However, much of the work has focused on a few aspects, particularly the bacterial component of the microbiome, most frequently in the gastrointestinal tract. Yet humans and other animals can be colonized by a wide array of organisms spanning all domains of life, including bacteria and archaea, unicellular eukaryotes such as fungi, multicellular eukaryotes such as helminths, and viruses. As they share the same host niches, they can compete with, synergize with, and antagonize each other, with potential impacts on their host. Here, we discuss these major groups making up the human microbiome, with a focus on how they interact with each other and their multicellular host.

中文翻译：

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微生物组中的跨域和病毒相互作用。

微生物组对人类健康的重要性日益得到认识，并已成为近期研究的主要焦点。然而，大部分工作都集中在几个方面，特别是微生物组的细菌成分，最常见的是胃肠道。然而，人类和其他动物可能被涵盖生命各个领域的多种生物体定殖，包括细菌和古细菌、真菌等单细胞真核生物、蠕虫等多细胞真核生物和病毒。由于它们共享相同的宿主生态位，因此它们可以相互竞争、协同和对抗，从而对其宿主产生潜在影响。在这里，我们讨论构成人类微生物组的这些主要群体，重点关注它们如何彼此相互作用以及它们的多细胞宿主如何相互作用。