Ribosyl 1,5-bisphosphate (PRibP) was discovered 65 years ago and was believed to be an important intermediate in ribonucleotide metabolism, a role immediately taken over by its "big brother" phosphoribosyldiphosphate. Only recently has PRibP come back into focus as an important player in the metabolism of ribonucleotides with the discovery of the pentose bisphosphate pathway that comprises, among others, the intermediates PRibP and ribulose 1,5-bisphosphate (cf. ribose 5-phosphate and ribulose 5-phosphate of the pentose phosphate pathway). Enzymes of several pathways produce and utilize PRibP not only in ribonucleotide metabolism but also in the catabolism of phosphonates, i.e., compounds containing a carbon-phosphorus bond. Pathways for PRibP metabolism are found in all three domains of life, most prominently among organisms of the archaeal domain, where they have been identified either experimentally or by bioinformatic analysis within all of the four main taxonomic groups, Euryarchaeota, TACK, DPANN, and Asgard. Advances in molecular genetics of archaea have greatly improved the understanding of the physiology of PRibP metabolism, and reconciliation of molecular enzymology and three-dimensional structure analysis of enzymes producing or utilizing PRibP emphasize the versatility of the compound. Finally, PRibP is also an effector of several metabolic activities in many organisms, including higher organisms such as mammals. In the present review, we describe all aspects of PRibP metabolism, with emphasis on the biochemical, genetic, and physiological aspects of the enzymes that produce or utilize PRibP. The inclusion of high-resolution structures of relevant enzymes that bind PRibP provides evidence for the flexibility and importance of the compound in metabolism.

中文翻译：

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败类化合物：1,5-双磷酸核糖酯作为代谢的重要参与者。

1，5-二磷酸核糖基（PRibP）于65年前被发现，被认为是核糖核苷酸代谢的重要中间体，这一作用立即被其“大哥”磷酸核糖二磷酸所取代。直到最近，PRibP作为核糖核苷酸代谢的重要参与者才重新受到关注，因为发现了戊糖双磷酸途径，其中包括中间体PRibP和核糖1,5-双磷酸（参见核糖5-磷酸和核糖）戊糖磷酸途径的5-磷酸）。几种途径的酶不仅在核糖核苷酸代谢中而且在膦酸酯（即含有碳-磷键的化合物）的分解代谢中产生并利用PRibP。PRibP代谢的途径存在于生活的所有三个领域，在古细菌领域的生物中最为突出，通过实验或通过生物信息学分析在四个主要分类组（Euryarchaeota，TACK，DPANN和Asgard）中均已鉴定出它们。古细菌的分子遗传学进展极大地增进了人们对PRibP代谢生理学的理解，分子酶学的调和以及产生或利用PRibP的酶的三维结构分析强调了该化合物的多功能性。最后，PRibP还是许多生物体（包括高等生物体，例如哺乳动物）中几种代谢活动的效应子。在本综述中，我们描述了PRibP代谢的所有方面，重点是产生或利用PRibP的酶的生化，遗传和生理方面。