Metastasis is the direst face of cancer, and it is not a feature solely dependent on cancer cells; however, a complex interaction between cancer cells and host causes this process. Investigating the mechanisms of metastasis can lead to its control. Myeloid-derived suppressor cells (MDSCs) are key components of tumor microenvironment that favor cancer progression. These cells result from altered myelopoiesis in response to the presence of tumor. The most recognized function of MDSCs is suppressing anti-tumor immune responses. Strikingly, these cells are among important players in cancer dissemination and metastasis. They can exert their effect on metastatic process by affecting anti-cancer immunity, epithelial-mesenchymal transition, cancer stem cell formation, angiogenesis, establishing premetastatic niche, and supporting cancer cell survival and growth in metastatic sites. In this article, we review and discuss the mechanisms by which MDSCs contribute to cancer metastasis.

中文翻译：

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髓样抑制细胞在癌症转移中的作用：免疫抑制及其他。

转移是癌症的最重要的方面，它不是仅依赖癌细胞的特征。然而，癌细胞与宿主之间复杂的相互作用导致了这一过程。研究转移的机制可以导致其控制。骨髓来源的抑制细胞（MDSC）是肿瘤微环境中有利于癌症进展的关键成分。这些细胞是由于对肿瘤的存在作出反应而改变了骨髓生成的结果。MDSC最公认的功能是抑制抗肿瘤免疫反应。令人惊讶的是，这些细胞是癌症传播和转移的重要参与者。他们可以通过影响抗癌免疫力，上皮-间质转化，癌症干细胞形成，血管生成，建立转移前的生态位，从而对转移过程发挥作用。并支持癌细胞在转移部位的存活和生长。在本文中，我们回顾并讨论了MDSC促进癌症转移的机制。