Glycoprotein non-metastatic protein B (GPNMB) is a transmembrane glycoprotein that is highly expressed in several malignancies compared with its expression in matched healthy tissues. The aim of this study was to investigate the clinical characteristics and prognostic value of GPNMB expression in tumor tissue derived from a cohort of patients with head and neck squamous cell carcinoma (HNSCC). GPNMB expression in human HNSCC, oral dysplasia and normal mucosal tissue was evaluated by immunohistochemistry (IHC). The correlations of GPNMB expression with the clinical characteristics of HNSCC were assessed by one-way ANOVA and t test analyses. Survival data were analyzed using Kaplan-Meier analysis and the Cox proportional hazards model. GPNMB was highly expressed in HNSCC tissue compared with dysplasia and normal mucosal tissue. Additionally, a high level of GPNMB expression in HNSCC was associated with poor prognosis (P<0.01). In the analysis of tumor-node-metastasis (TNM) staging, a high GPNMB expression level in HNSCC tissue, as well as metastatic lymph node tissue, correlated with an advanced N stage. In conclusion, GPNMB was overexpressed in human HNSCC tissue and predicted poor prognosis in human HNSCC tissue. In addition, GPNMB expression was closely correlated with N stage in patients with HNSCC.

中文翻译：

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GPNMB的高表达预示着头颈部鳞状细胞癌的预后不良。

糖蛋白非转移蛋白B（GPNMB）是一种跨膜糖蛋白，与在匹配的健康组织中的表达相比，它在几种恶性肿瘤中都高度表达。这项研究的目的是调查头颈部鳞状细胞癌（HNSCC）患者队列的肿瘤组织中GPNMB表达的临床特征和预后价值。通过免疫组织化学（IHC）评估人HNSCC，口腔发育不良和正常粘膜组织中GPNMB的表达。通过单因素方差分析和t检验分析评估了GPNMB表达与HNSCC临床特征的相关性。使用Kaplan-Meier分析和Cox比例风险模型分析生存数据。与不典型增生和正常粘膜组织相比，GPNMB在HNSCC组织中高表达。另外，HNSCC中GPNMB表达水平高与预后不良有关（P <0.01）。在肿瘤淋巴结转移（TNM）分期的分析中，HNSCC组织以及转移性淋巴结组织中较高的GPNMB表达水平与晚期N期相关。总之，GPNMB在人HNSCC组织中过表达，并预测在人HNSCC组织中预后不良。此外，HNSCC患者中GPNMB的表达与N期密切相关。