Intestinal ischemia-reperfusion (IR) injury is a frequent, but potentially life-threatening condition. Although much has been learned about its pathophysiology from animal IR models, the translation to the human setting is imperative for better understanding of its etiology. This could provide us with new insight into development of early detection and potential new therapeutic strategies. Over the past decade, we have studied the pathophysiology of human small intestinal and colonic ischemia-reperfusion (IR) in newly developed human in vivo IR models. In this review, we give an overview of new insights on the sequelae of human intestinal IR, with particular attention for the differences in histopathology between small intestinal and colonic IR.

中文翻译：

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人类小肠和结肠缺血再灌注的组织病理学：人类IR模型的经验。

肠缺血再灌注（IR）损伤是一种常见但可能危及生命的疾病。尽管已经从动物IR模型中获得了许多有关其病理生理学的信息，但是必须更好地理解其病因才能转化为人类环境。这可以为我们提供有关早期发现和潜在新治疗策略开发的新见识。在过去的十年中，我们在新开发的人类体内IR模型中研究了人类小肠和结肠缺血再灌注（IR）的病理生理。在这篇综述中，我们概述了关于人类肠道IR后遗症的新见解，并特别关注了小肠IR与结肠IR之间组织病理学的差异。