Chemotherapy is one of the most common treatments for cancer; however, a side effect is often altered taste. This study examined how cyclophosphamide, a chemotherapy drug, affects salt taste in mice. On the basis of previous findings, it was predicted that cyclophosphamide-induced disruptions in salt taste would be observed near days 2-4, 8-12, and 22-24 posttreatment, and that multiple, smaller doses would cause more severe disruptions to taste. To test these predictions, two experiments were performed, one using brief access testing to measure appetitive qualities, and another using operant conditioning to measure detection thresholds. After a single 100 mg/kg cyclophosphamide injection, peak alterations in brief access lick rates were seen near days 5-8 and 15 posttreatment, whereas peak alterations in detection thresholds were seen days 6, 14, and 20 posttreatment. After five 20 mg/kg injections of cyclophosphamide, brief access lick rates revealed disruptions only on postinjection day 8 whereas thresholds appeared to cycle, gradually increased to and decreased from peak elevations on posttreatment days 4, 10, 15, 20, and 23. Although salt taste functions were disrupted by cyclophosphamide, the patterns of these disruptions were less severe and shorter than expected from cell morphology studies, suggesting a functional adjustment to maintain behavioral accuracy. Fractionation of cyclophosphamide dosing had minimum effect on brief access responses but caused longer, cyclic-like disruptions of detection thresholds compared to single-dose administration.

中文翻译：

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环磷酰胺对NaCl的竞争质量和检测阈值的干扰：单剂量和剂量分馏效应的比较。

化学疗法是最常见的癌症治疗方法之一。然而，副作用通常是改变口味。这项研究检查了化疗药物环磷酰胺如何影响小鼠的盐味。根据以前的发现，预计在处理后第2-4天，第8-12天和第22-24天附近会观察到环磷酰胺引起的盐味破坏，并且多次较小剂量会导致更严重的味觉破坏。为了测试这些预测，进行了两个实验，一个实验是使用简短访问测试来测量食欲质量，另一个实验是使用操作条件来测量检测阈值。单次注射100 mg / kg环磷酰胺后，在治疗后第5-8天和第15天观察到短暂舔食率出现峰值变化，而在检测阈值第6、14天出现峰值变化。和20后处理。在五次20 mg / kg的环磷酰胺注射后，短暂的舔舔率显示仅在注射后第8天出现破坏，而阈值似乎在上升，并在治疗后第4、10、15、20和23天逐渐从峰值升高逐渐降低。盐味功能被环磷酰胺破坏，这些破坏的模式比细胞形态学研究所预期的严重程度要短，并且要短，这表明可以进行功能调整以保持行为准确性。与单剂量给药相比，分次环磷酰胺给药对短暂的访问反应影响最小，但会导致更长的，环状的检测阈值中断。短暂的舔舔率显示仅在注射后第8天出现破坏，而阈值似乎循环，在治疗后第4、10、15、20和23天从峰值升高逐渐升高和降低，尽管盐味功能被环磷酰胺破坏，但模式这些中断的严重程度比细胞形态学研究预期的要短，并且比预期的短，这表明可以进行功能调整以保持行为准确性。与单剂量给药相比，分次环磷酰胺给药对短暂的访问反应影响最小，但会导致更长的，环状的检测阈值中断。短暂的舔舔率显示仅在注射后第8天出现破坏，而阈值似乎循环，在治疗后第4、10、15、20和23天从峰值升高逐渐升高和降低，尽管盐味功能被环磷酰胺破坏，但模式这些中断的严重程度比细胞形态学研究预期的要短，并且比预期的短，这表明可以进行功能调整以保持行为准确性。与单剂量给药相比，分次环磷酰胺给药对短暂的访问反应影响最小，但会导致更长的，环状的检测阈值中断。尽管盐味功能被环磷酰胺破坏，但这些破坏的模式比细胞形态学研究所预期的严重程度要短且短，这表明可以进行功能调节以保持行为准确性。与单剂量给药相比，分次给予环磷酰胺的剂量对短暂进入反应的影响最小，但会导致更长的，环状的检测阈值中断。尽管盐味功能被环磷酰胺破坏，但这些破坏的模式比细胞形态学研究所预期的严重程度要短且短，这表明可以进行功能调节以保持行为准确性。与单剂量给药相比，分次环磷酰胺给药对短暂的访问反应影响最小，但会导致更长的，环状的检测阈值中断。