Differentiation from RAW264.7 cells to osteoclasts rely on many signaling pathways, such as NF-κB, MAPK, Akt and others. However, the specific underlying mechanisms are not clear. Recently, much works have focused on the inhibitory effects of plant derived compounds in the differentiation from RAW264.7 to osteoclasts. However, the specific mechanisms remain unclear. In this paper, we summarize a lot of plant derived compounds which exert blocking effect on the progression of differentiation via signaling pathways.

中文翻译：

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草药化合物抑制巨噬细胞线性RAW264.7破骨细胞生成的分子机制概述。

从RAW264.7细胞到破骨细胞的分化依赖于许多信号通路，例如NF-κB，MAPK，Akt等。但是，具体的潜在机制尚不清楚。近来，许多工作集中于植物衍生化合物在从RAW264.7向破骨细胞的分化中的抑制作用。但是，具体机制仍不清楚。在本文中，我们总结了许多植物衍生的化合物，它们通过信号传导途径对分化的进程产生阻断作用。