Pelvic floor disorders (PFDs) will affect most women during their lifetime. Sequelae such as pelvic organ prolapse, stress urinary incontinence, chronic pain and dyspareunia significantly impact overall quality of life. Interventions to manage or eliminate symptoms from PFDs aim to restore support of the pelvic floor. Pessaries have been used to mechanically counteract PFDs for thousands of years, but do not offer a cure. By contrast, surgically implanted grafts or mesh offer patients a more permanent resolution but have been in wide use within the pelvis for less than 30 years. In this perspective review, we provide an overview of the main theories underpinning PFD pathogenesis and the animal models used to investigate it. We highlight the clinical outcomes of mesh and grafts before exploring studies performed to elucidate tissue level effects and bioengineering considerations. Considering recent turmoil surrounding transvaginal mesh, the role of pessaries, an impermanent method, is examined as a means to address patients with PFDs.

中文翻译：

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处理女性骨盆底障碍：医疗设备的审查和评估。

骨盆底疾病（PFD）将影响大多数妇女的一生。后遗症，例如盆腔器官脱垂，压力性尿失禁，慢性疼痛和性交困难等，都会严重影响整体生活质量。通过干预来控制或消除PFD的症状，旨在恢复对骨盆底的支持。子宫托已经被用于机械抵消PFD几千年了，但是不能提供治愈方法。相比之下，通过外科手术植入的移植物或网片可为患者提供更持久的分辨率，但在骨盆内已广泛使用了不到30年。在这一观点综述中，我们提供了支持PFD发病机理的主要理论概述以及用于研究它的动物模型的概述。在探讨为阐明组织水平影响和生物工程考虑因素而进行的研究之前，我们将重点介绍网状和移植物的临床结果。考虑到最近经阴道网周围的动荡，检查了子宫托的作用，这是一种无常的方法，可作为解决PFD患者的一种手段。