Myocardial damage could develop asymptomatically through nonischemic mechanisms such as cardiac overload. This study investigated possible associations between electrocardiogram (ECG) findings relevant to the QRS wave and high-sensitivity cardiac troponin I (hs-cTnI) in the general population. Subjects undergoing their annual health checkup were enrolled in the study (n = 1258). ECG features relevant to the QRS wave that were investigated included PQ interval, QRS voltage (Sokolow-Lyon voltage), QRS duration, product of QRS duration and voltage (Cornell product), corrected QT interval, and QRS axis. Laboratory measurements included hs-cTnI and B-type natriuretic peptide. hs-cTnI was significantly higher in subjects with a long PQ interval, high Sokolow-Lyon voltage, wide QRS duration, increased Cornell product, long corrected QT interval, or left QRS axis deviation. Univariate and multivariate regression analysis showed that Sokolow-Lyon voltage, QRS duration, and Cornell product were significantly associated with hs-cTnI after adjustment for possible confounding factors, including B-type natriuretic peptide. Logistic regression analysis with the endpoint of higher hs-cTnI than the median value showed that Sokolow-Lyon voltage and Cornell product were independently associated with increased hs-cTnI concentrations. ECG findings relevant to the QRS wave, especially increased QRS voltage, are associated with hs-cTnI in the general population.

中文翻译：

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静息心电图中与QRS波相关的发现与普通人群中高敏感性心脏肌钙蛋白I的循环浓度有关。

心肌损伤可通过非缺血性机制（如心脏超负荷）无症状地发展。这项研究调查了一般人群中与QRS波相关的心电图（ECG）结果与高敏感性心脏肌钙蛋白I（hs-cTnI）之间的可能关联。接受年度健康检查的受试者入选了该研究（n = 1258）。与QRS波相关的ECG特征包括PQ间隔，QRS电压（Sokolow-Lyon电压），QRS持续时间，QRS持续时间与电压的乘积（康奈尔乘积），校正后的QT间隔和QRS轴。实验室测量包括hs-cTnI和B型利钠肽。在PQ间隔长，Sokolow-Lyon电压高，QRS持续时间宽，康奈尔乘积增加，QT校正间隔长，或左QRS轴偏差。单因素和多因素回归分析表明，在调整可能的混杂因素（包括B型利钠肽）后，Sokolow-Lyon电压，QRS持续时间和Cornell乘积与hs-cTnI显着相关。Logistic回归分析的hs-cTnI高于中值终点，表明Sokolow-Lyon电压和康奈尔积与hs-cTnI浓度升高独立相关。与QRS波有关的ECG发现（尤其是QRS电压升高）与普通人群中的hs-cTnI有关。包括B型利钠肽。Logistic回归分析的hs-cTnI高于中值终点，表明Sokolow-Lyon电压和康奈尔积与hs-cTnI浓度升高独立相关。与QRS波有关的ECG发现（尤其是QRS电压升高）与普通人群中的hs-cTnI有关。包括B型利钠肽。Logistic回归分析的hs-cTnI高于中值终点，表明Sokolow-Lyon电压和康奈尔积与hs-cTnI浓度升高独立相关。与QRS波有关的ECG发现（尤其是QRS电压升高）与普通人群中的hs-cTnI有关。