Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of neutrophil infiltration, stimulation of the clearance of apoptotic cells by macrophages, and promotion of tissue remodeling and homeostasis. Metabolic dysregulation due to either uncontrolled activity of pro-inflammatory responses or to inefficient resolution of inflammation results in chronic inflammation and may also lead to atherosclerosis or other chronic autoimmune diseases such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus, vasculitis, inflammatory bowel diseases, and type 1 diabetes mellitus. The pathogenesis of such diseases involves a complex interplay between the immune system and, environmental factors (non-infectious or infectious), and critically depends on individual susceptibility to such factors. In the present review, resolvins and their roles in the resolution of inflammation, as well as the role of these mediators as potential therapeutic agents to counteract specific chronic autoimmune and inflammatory diseases are discussed.

中文翻译：

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Resolvins：自身免疫和炎性疾病的新兴参与者。

Resolvins属于专业的促溶介质（SPM），是omega-3多不饱和脂肪酸（ω-3PUFA）的代谢产物，在急性炎症反应的初始阶段合成，以促进炎症的消退。产生Resolvins用于终止嗜中性粒细胞浸润，刺激巨噬细胞刺激凋亡细胞的清除以及促进组织重塑和体内平衡。由于促炎反应的活动不受控制或炎症的无效解决而导致的代谢失调会导致慢性炎症，还可能导致动脉粥样硬化或其他慢性自身免疫性疾病，例如类风湿性关节炎，牛皮癣，系统性红斑狼疮，血管炎，炎症性肠病，和1型糖尿病。此类疾病的发病机制涉及免疫系统与环境因素（非传染性或传染性）之间的复杂相互作用，并且严重取决于个人对此类因素的敏感性。在本综述中，讨论了分辨蛋白及其在炎症消退中的作用，以及这些介体作为抵抗特定慢性自身免疫和炎症性疾病的潜在治疗剂的作用。