We investigated the effects of exercise in multiple sessions on anxiety- and depression-like behavior during aging, and the role of serotonin and serotonin 1A receptors in this process. Both 24-month-old (aged) and 6-month-old (adult) female rats were divided into five groups; aged control, adult control, aged + serotonin re-uptake inhibitors (SSRIs), aged + exercise, and aged + SSRIs + exercise. After exercise, all groups were evaluated using the open field arena, elevated plus maze and forced swim tests. We assessed serum corticosterone levels; number of amygdala, hippocampus and prefrontal cortex cells; tissue serotonin and serotonin 1A (5-HT1A) levels. In the open field test, aged rats exhibited a significant increase in locomotor activity compared to the SSRIs and SSRIs + exercise groups. During the elevated plus maze test, aged rats were observed less frequently in the open arms of assembly compared to adults. The duration increased in the exercise group and remained unchanged in the SSRIs group. In the forced swim test, the aged rats were more immobile compared to adults; no change was observed in the immobility time between these groups. The tissue serotonin levels in amygdala and hippocampus were higher in SSRIs + exercise group compared to the aged, exercised and SSRIs groups. The number of cells in the hippocampus, prefrontal cortex and amygdala decreased in the aged group compared to adult rats; increased numbers of cell were observed in exercise, SSRIs and SSRIs + exercise groups compared to aged rats. Exercise in multiple sessions may increase the number of cells in the hippocampus, prefrontal cortex and amygdala, which may reduce senile anxiety and depression. Also, serotonin and serotonin 1A receptors may play role in depression-like behavior.

中文翻译：

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运动对老年大鼠焦虑和抑郁样行为的影响。

我们调查了运动对衰老过程中焦虑和抑郁样行为的影响，以及5-羟色胺和5-羟色胺1A受体在此过程中的作用。将24月龄（成年）和6个月龄（成年）的雌性大鼠分为五组；每组5只。老年对照，成人对照，老年+血清素再摄取抑制剂（SSRIs），老年+运动和老年+ SSRIs +运动。运动后，使用露天场地，高架迷宫和强迫游泳测试对所有组进行评估。我们评估了血清皮质酮水平；杏仁核，海马和前额叶皮层细胞的数量；组织血清素和血清素1A（5-HT1A）的水平。在野外试验中，与SSRIs和SSRIs +运动组相比，老年大鼠的自发活动显着增加。在高架迷宫测试中，与成年动物相比，在装配的张开双臂中观察到老年大鼠的频率更低。运动组的持续时间增加，而SSRIs组则保持不变。在强制游泳测试中，与成年大鼠相比，成年大鼠更不活动。这些组之间的固定时间没有变化。SSRIs +运动组的杏仁核和海马组织中的血清素水平高于老年，运动和SSRIs组。与成年大鼠相比，老年组海马，前额叶皮层和杏仁核中的细胞数量减少；与老年大鼠相比，在运动，SSRIs和SSRIs +运动组中观察到细胞数量增加。多节运动可能会增加海马，前额叶皮层和杏仁核中的细胞数量，可以减轻老年性焦虑和抑郁。另外，血清素和血清素1A受体可能在抑郁样行为中起作用。