Ovarian cancer has a high mortality rate. Serous carcinoma is the most common subtype and can be detected by distant or lymph node metastasis in advanced stages. Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in lymphatic invasion. Angiogenesis also can affect lymph node involvement in serous ovarian carcinomas. We investigated apelin/APJ receptor immunoreactivity in stages III and IV ovarian cancer with or without lymph node involvement and correlated the results with body mass index (BMI) to determine whether the potential relation of the two affects the outcome of the cancer. We investigated 30 patients diagnosed between 2014 and 2016 with high grade serous ovarian cancer. Tumor:stroma ratio, indirect immunoperoxidase method, H-score and MATLAB analysis were performed. In obese and pre-obese patients, tumor apelin immunoreactivity was stronger than for patients with normal BMI. Tumor:stroma ratio was correlated with survival and lymph node involvement. Strong apelin and moderate APJ immunoreactivity was detected in both lymph node negative and positive patients. BMI was related to both survival outcome and apelin immunoreactivity. BMI, adipokines such as apelin, and the stromal compartment play critical roles in advanced stage serous carcinomas.

中文翻译：

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卵巢高级别浆液性癌的肿瘤apelin免疫反应性与体重指数相关。

卵巢癌死亡率高。浆液性癌是最常见的亚型，晚期可通过远处或淋巴结转移进行检测。与肥胖有关的脂肪因子Apelin及其受体APJ参与淋巴管浸润。血管生成还可以影响浆液性卵巢癌的淋巴结受累。我们调查了III期和IV期卵巢癌伴或不伴淋巴结受累的apelin / APJ受体的免疫反应性，并将结果与​​体重指数（BMI）相关联，以确定两者的潜在关系是否会影响癌症的预后。我们调查了2014年至2016年之间被诊断患有高度浆液性卵巢癌的30例患者。进行肿瘤：基质比，间接免疫过氧化物酶法，H值和MATLAB分析。在肥胖和肥胖前期的患者中，肿瘤apelin的免疫反应性强于BMI正常的患者。肿瘤：基质比率与生存率和淋巴结受累相关。淋巴结阴性和阳性患者均检测到强的apelin和中等的APJ免疫反应性。BMI与生存结果和apelin免疫反应性有关。在晚期浆液性癌中，BMI，诸如apelin的脂肪因子和基质区隔起着关键作用。