Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by micro RNA 146a and 147b in vitro,Neuropathology and Applied Neurobiology

当前位置： X-MOL 学术 › Neuropathol. Appl. Neurobiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by micro RNA 146a and 147b in vitro
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2019-07-01 , DOI: 10.1111/nan.12572
D W M Broekaart ₁ , J van Scheppingen ₁ , J J Anink ₁ , L Wierts _{2,

3} , B van Het Hof ₃ , F E Jansen ₄ , W G Spliet ₅ , P C van Rijen ₆ , W W Kamphuis _{2,

3} , H E de Vries ₃ , E Aronica _{1,

7} , E A van Vliet _{1,

8}

Affiliation

Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) control proteolysis within the extracellular matrix (ECM) of the brain. Dysfunction of this enzymatic system due to brain inflammation can disrupt the blood‐brain barrier (BBB) and has been implicated in the pathogenesis of epilepsy. However, this has not been extensively studied in the epileptogenic human brain.

中文翻译：

结节性硬化症复合体中基质金属蛋白酶表达增加：体外微小 RNA 146a 和 147b 的调节

基质金属蛋白酶 (MMP) 及其内源性组织抑制剂 (TIMP) 控制大脑细胞外基质 (ECM) 内的蛋白水解作用。由于脑部炎症导致的酶系统功能障碍会破坏血脑屏障（BBB），并且与癫痫的发病机制有关。然而，这尚未在致癫痫的人脑中得到广泛研究。

更新日期：2019-07-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11