This study was designed to evaluate the spatial working memory (as studied in Y-maze) or short-term and long-term spatial memory (assessed in radial 8 arms-maze task), in a scopolamine-induced memory deficits model in mice, by the oral administration of 2 angiotensin-converting enzyme inhibitors-captopril and ramipril and also the effects of the AT1 receptor antagonist, losartan. The present article was initiated as a reaction to the clinical setting of hypertensive disease, which involves lifelong administration of antihypertensive drugs, dietary or lifestyle constraints, and aging, which all take a toll on the higher functions of the nervous system. Most of the patients with cognitive decline suffer of various metabolic imbalances, hypertension, cardiac and kidney disease, many of them which are treated with oral administration of Renin-angiotensin aldosterone system-altering agents like those presented above. Our results showed a protective effect of captopril, ramipril, and losartan prescopolamine administration on spontaneous alternation in Y-maze task, as compared to scopolamine-alone treated mice, as well as decreased number of working memory errors and reference memory errors in radial-arm maze for both losartan + scopolamine and ramipril + scopolamine groups versus scopolamine alone. This could have a therapeutical relevance, especially since oral administration was preferred in our report, as it is used in the therapeutic procedures in humans, further enhancing the similarities with the clinical conditions.

中文翻译：

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口服肾素-血管紧张素系统改变药物对东莨菪碱治疗小鼠记忆增强作用的比较研究。


本研究旨在评估东莨菪碱诱导的小鼠记忆缺陷模型中的空间工作记忆（在 Y 迷宫中研究）或短期和长期空间记忆（在径向 8 臂迷宫任务中评估），通过口服2种血管紧张素转换酶抑制剂卡托普利和雷米普利以及AT1受体拮抗剂氯沙坦的作用。本文的发起是为了对高血压疾病的临床情况做出反应，高血压疾病涉及终生服用抗高血压药物、饮食或生活方式限制以及衰老，这些都会对神经系统的高级功能造成损害。大多数认知能力下降的患者患有各种代谢失衡、高血压、心脏和肾脏疾病，其中许多患者通过口服肾素-血管紧张素醛固酮系统改变剂（如上所述）进行治疗。我们的结果表明，与单独使用东莨菪碱治疗的小鼠相比，卡托普利、雷米普利和氯沙坦前东莨菪碱给药对 Y 迷宫任务中的自发交替具有保护作用，并且减少了放射臂中的工作记忆错误和参考记忆错误数量氯沙坦+东莨菪碱组和雷米普利+东莨菪碱组与单独东莨菪碱组的迷宫。这可能具有治疗相关性，特别是因为我们的报告中首选口服给药，因为它用于人类的治疗过程，进一步增强了与临床状况的相似性。