Alzheimer's disease (AD), a neurological disorder, is as a complex chronic disease of brain cell death that usher to cognitive decline and loss of memory. Its prevalence differs according to risk factors associated with it and necropsy performs vital role in its definite diagnosis. The stages of AD vary from preclinical to severe that proceeds to death of patient with no availability of treatment. Biomarker may be a biochemical change that can be recognized by different emerging technologies such as proteomics and metabolomics. Plasma biomarkers, 5-protein classifiers, are readily being used for the diagnosis of AD and can also predict its progression with a great accuracy, specificity, and sensitivity. In this review, upregulation or downregulation of few plasma proteins in patients with AD has also been discussed, when juxtaposed with control, and thus serves as potent biomarker in the diagnosis of AD.

中文翻译：

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血浆生物标志物：阿尔茨海默病的有效筛查工具。


阿尔茨海默病（AD）是一种神经系统疾病，是一种复杂的脑细胞死亡慢性疾病，会导致认知能力下降和记忆丧失。其患病率根据与其相关的危险因素而异，尸检在其明确诊断中起着至关重要的作用。 AD 的阶段各异，从临床前到严重，直至患者无法接受治疗而死亡。生物标志物可能是一种可以被蛋白质组学和代谢组学等不同新兴技术识别的生化变化。血浆生物标志物、5 蛋白分类器很容易用于 AD 的诊断，并且还可以以极高的准确性、特异性和敏感性预测其进展。在这篇综述中，还讨论了 AD 患者中少数血浆蛋白的上调或下调，与对照相比，因此可作为 AD 诊断中的有效生物标志物。