Inflammation is the host response against stresses such as infection. Although the inflammation process is required for the elimination of pathogens, uncontrolled inflammation leads to tissue destruction and inflammatory diseases. To avoid this, the inflammatory response is tightly controlled by multiple layers of regulation. Post-transcriptional control of inflammatory mRNAs is increasingly understood to perform critical roles in this process. This is mediated primarily by a set of RNA binding proteins (RBPs) including tristetraprolin, Roquin and Regnase-1, and RNA methylases. These key regulators coordinate the inflammatory response by modulating mRNA pools in both immune and local nonimmune cells. In this review, we provide an overview of the post-transcriptional coordination of immune responses in various tissues and discuss how RBP-mediated regulation of inflammation may be harnessed as a potential class of treatments for inflammatory diseases.

中文翻译：

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转录后的免疫反应控制及其潜在应用。

炎症是宿主应对压力（如感染）的反应。尽管消灭病原体需要炎症过程，但是不受控制的炎症会导致组织破坏和炎症性疾病。为了避免这种情况，炎症反应受到多层调节的严格控制。炎症mRNA的转录后控制越来越被理解为在此过程中起关键作用。这主要是由一组RNA结合蛋白（RBP）介导的，包括Tristetraprolin，Roquin和Regnase-1，以及RNA甲基化酶。这些关键调节因子通过调节免疫和局部非免疫细胞中的mRNA池来协调炎症反应。在这篇评论中