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Proportion of Cytotoxic Peripheral Blood Natural Killer Cells and T-Cell Large Granular Lymphocytes in Recurrent Miscarriage and Repeated Implantation Failure: Case-Control Study and Meta-analysis.
Archivum Immunologiae et Therapiae Experimentalis ( IF 2.9 ) Pub Date : 2019-05-30 , DOI: 10.1007/s00005-019-00546-5
Kamila Kolanska 1 , Ludovic Suner 2 , Jonathan Cohen 1 , Yasmine Ben Kraiem 1 , Leo Placais 3 , Olivier Fain 3 , Marie Bornes 1 , Lise Selleret 1 , François Delhommeau 2 , Frédéric Feger 2 , Emmanuelle Mathieu d'Argent 1 , Emile Darai 1 , Nathalie Chabbert-Buffet 1 , Jean-Marie Antoine 1 , Gilles Kayem 4 , Arsène Mekinian 3, 5
Affiliation  

We aimed to compare the proportion of peripheral blood natural killer (NK) cells (CD3-CD56+) and T-cell large granular lymphocytes (CD8+CD57+) during preconception in a homogenous group of women with unexplained well-defined recurrent miscarriage (RM) and repeated implantation failure (RIF) vs healthy controls in relation to pregnancy outcomes. This case-control study followed by a literature review and meta-analysis was conducted in three university hospitals. Patients and controls were consecutively recruited from December 2015 to October 2017. In total, 115 women were included in the study: 54 with RM, 41 with RIF and 20 healthy controls with ≥ 2 term births. Percentages of CD3-CD56+ and CD8+CD57+ cells and sub-populations of CD3-CD56+ cells did not differ between cases and controls. The results for women with subsequent miscarriage did not differ from those with live births. The meta-analysis of the literature showed higher NK-cell proportions in RM [mean difference 3.47 (95% CI 2.94-4.00); p < 0.001] and RIF [mean difference 1.64 (95% CI 0.82-2.45); p < 0.001] than controls. However, the heterogeneity between the different studies was high. The proportion of peripheral blood CD3-CD56+ and CD8+CD57+ cells in the preconception period does not reflect the risk of implantation failure or miscarriage and should not be recommended indicators for the management of RM and RIF. Further prospective large studies are needed to develop a reliable peripheral blood marker of immune deregulation.

中文翻译:

反复流产和反复植入失败中细胞毒性外周血自然杀伤细胞和T细胞大颗粒淋巴细胞的比例:病例对照研究和荟萃分析。

我们的目的是比较同种原因不明的明确反复流产(RM)的同种女性在受孕前外周血自然杀伤(NK)细胞(CD3-CD56 +)和T细胞大颗粒淋巴细胞(CD8 + CD57 +)的比例以及与妊娠结局有关的反复植入失败(RIF)与健康对照组的比较。在三所大学医院进行了病例对照研究,随后进行了文献综述和荟萃分析。从2015年12月至2017年10月连续招募患者和对照组。研究共纳入115名妇女:54名RM,41名RIF和20名≥2个足月出生的健康对照组。病例和对照组之间,CD3-CD56 +和CD8 + CD57 +细胞的百分比以及CD3-CD56 +细胞的亚群没有差异。随后流产的妇女的结果与活产妇女的结果没有差异。文献的荟萃分析显示RM中较高的NK细胞比例[平均差异3.47(95%CI 2.94-4.00; p <0.001]和RIF [均差1.64(95%CI 0.82-2.45);p <0.001]。但是,不同研究之间的异质性很高。在受孕前期外周血CD3-CD56 +和CD8 + CD57 +细胞的比例不能反映植入失败或流产的风险,因此不应作为管理RM和RIF的推荐指标。需要进一步的前瞻性大型研究来开发可靠的外周血免疫失调标志物。94-4.00);p <0.001]和RIF [均差1.64(95%CI 0.82-2.45);p <0.001]。但是,不同研究之间的异质性很高。在受孕前期外周血CD3-CD56 +和CD8 + CD57 +细胞的比例不能反映植入失败或流产的风险,因此不应作为管理RM和RIF的推荐指标。需要进一步的前瞻性大型研究来开发可靠的外周血免疫失调标志物。94-4.00);p <0.001]和RIF [均差1.64(95%CI 0.82-2.45);p <0.001]。但是,不同研究之间的异质性很高。在受孕前期外周血CD3-CD56 +和CD8 + CD57 +细胞的比例不能反映植入失败或流产的风险,因此不应作为管理RM和RIF的推荐指标。需要进一步的前瞻性大型研究来开发可靠的外周血免疫失调标志物。在受孕前期外周血CD3-CD56 +和CD8 + CD57 +细胞的比例不能反映植入失败或流产的风险,因此不应作为管理RM和RIF的推荐指标。需要进一步的前瞻性大型研究来开发可靠的外周血免疫失调标志物。在受孕前期外周血CD3-CD56 +和CD8 + CD57 +细胞的比例不能反映植入失败或流产的风险,因此不应作为管理RM和RIF的推荐指标。需要进一步的前瞻性大型研究来开发可靠的外周血免疫失调标志物。
更新日期:2019-11-01
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