Gold nanoparticles (AuNPs) have been previously shown to induce gut dysbiosis during colitis in mice, but the underlying mechanism is not clear yet. Here, we evaluated the effects of AuNPs (5 nm diameter, coated with tannic acid, polyvinylpyrrolidone or citrate) on H2O2 accumulation and pathogen antagonization by an intestinal strain of Lactobacillus gasseri under aerobic cultural conditions. AuNPs (0.65 μg/mL) reduced over 50% of H2O2 accumulation by L. gasseri, and significantly inhibited the antagonistic action of L. gasseri on growth of four foodborne enteric pathogens, i.e. Salmonella enterica serovar Typhimurium, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus in associative cultures.

中文翻译：

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模拟过氧化氢酶的金纳米颗粒在关联培养中抑制了格氏乳杆菌对食源性肠道病原体的拮抗作用。

先前已显示，金纳米颗粒（AuNPs）会在小鼠结肠炎期间诱发肠道营养不良，但其潜在机制尚不清楚。在这里，我们评估了好氧培养条件下加氏乳杆菌肠菌株对AuNPs（直径5 nm，单宁酸，聚乙烯吡咯烷酮或柠檬酸盐包被）对过氧化氢积累和病原体拮抗的影响。AuNPs（0.65μg/ mL）减少了盖氏乳杆菌H2O2积累的50％以上，并显着抑制了盖氏乳杆菌对四种食源性肠病原菌，即肠炎沙门氏菌鼠伤寒沙门氏菌，大肠杆菌，单核细胞增生李斯特菌和金黄色葡萄球菌在联合培养中。