Neutrophils constitute the most numerous populations of peripheral blood leukocytes, fulfilling the fundamental role in the development of the innate immune response. As the cells of the first line of defense, they guard the organism against the spread of pathogenic microorganisms. Neutrophils, similar to the other cells of the immune system, enter the path of death after fulfilling their biological function. Depending on the conditions that they are found in, they may undergo different types of cell death which requires the involvement of numerous signaling pathways. In this review article, we summarize the current state of knowledge regarding the different forms of neutrophil death, such as apoptosis, necrosis, necroptosis, autophagy, NETosis and pyroptosis.

中性粒细胞构成了外周血白细胞的最大数量，在先天免疫反应的发展中起着基本作用。作为第一道防线的细胞，它们可以保护生物体免受病原微生物的扩散。中性粒细胞与免疫系统的其他细胞相似，在履行其生物学功能后进入死亡路径。取决于发现它们的条件，它们可能经历不同类型的细胞死亡，这需要许多信号传导途径的参与。在这篇综述文章中，我们总结了关于中性粒细胞死亡的不同形式的当前知识状态，例如凋亡，坏死，坏死性硬化，自噬，NETosis和发烧。