Campylobacteris a major foodborne pathogen and is commonly present in food producing animals. This pathogenic organism is highly adaptable and has become increasingly resistant to various antibiotics. Recently, both the Centers for Disease Control and Prevention and the World Health Organization have designated antibiotic-resistantCampylobacteras a serious threat to public health. For the past decade, multiple mechanisms conferring resistance to clinically important antibiotics have been described inCampylobacter, and new resistance mechanisms constantly emerge in the pathogen. Some of the recent examples include theerm(B)gene conferring macrolide resistance, thecfr(C)genes mediating resistance to florfenicol and other antimicrobials, and a functionally enhanced variant of the multidrug resistance efflux pump, CmeABC. The continued emergence of new resistance mechanisms illustrates the extraordinary adaptability ofCampylobacterto antibiotic selection pressure and demonstrate the need for innovative strategies to control antibiotic-resistantCampylobacter. In this review, we will briefly summarize the trends of antibiotic resistance inCampylobacterand discuss the mechanisms of resistance to antibiotics used for animal production and important for clinical therapy in humans. A special emphasis will be given to the newly discovered antibiotic resistance.

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食源性病原体弯曲杆菌的抗生素耐药趋势和机制

弯曲杆菌是一种主要的食源性病原体，通常存在于食用动物中。这种病原生物具有很强的适应性，并且对各种抗生素的抵抗力越来越强。最近，疾病控制和预防中心和世界卫生组织都指定了抗生素耐药性弯曲杆菌作为对公众健康的严重威胁。在过去的十年中，多种机制对临床上重要的抗生素产生耐药性已被描述为弯曲杆菌，并且病原体中不断出现新的抗性机制。最近的一些例子包括嗯(B)大环内酯类耐药基因cfr(C)介导对氟苯尼考和其他抗菌剂耐药的基因，以及多药耐药外排泵 CmeABC 的功能增强变体。新抗性机制的不断出现说明了弯曲杆菌抗生素选择压力，并证明需要创新策略来控制抗生素耐药性弯曲杆菌. 在这篇综述中，我们将简要总结抗生素耐药性的趋势。弯曲杆菌并讨论对用于动物生产和人类临床治疗重要的抗生素的耐药机制。将特别强调新发现的抗生素耐药性。