Background: Podoplanin is a transmembrane glycoprotein expressed on various normal or neoplastic cells. Some studies have shown that podoplanin promotes the migration and invasion of tumor cells. This study evaluated a podoplanin expression in Odontogenic Keratocysts (OKs) associated or not associated with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) and in Orthokeratinized Odontogenic Cysts (OOCs). Materials and Methods: A total of 50 lesions were obtained in this study, 28 OKs, 18 OKs associated with NBCCS, and 4 OOCs. Immunohistochemical expression of podoplanin in epithelial cells was evaluated using the following score: (a) intensity of immunostaining: (0: absent, 1: weak, 2: moderate, 3: strong, and 4: very strong) and (b) number of positively cells (0: 0%, 1: <25%, 2: 25% to 50%, 3: 50% to 75%, and 4: >75%). The final score was determined by adding the scores of a and b and ranged from 0 to 8 (0: absent, 1 to 4: weak, and 5 to 8: strong). Results: Podoplanin expression was significantly stronger in the basal layer OKs and NBCCS lesions. Further, podoplanin expression was the highest in the suprabasal layer of NBCCS lesions, followed by the suprabasal layers of OK and OOC lesions. Conclusions: Podoplanin expression is different in lesions of different biological behaviors. Podoplanin seems to play a role in cell proliferation and migration.

中文翻译：

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牙源性角化囊肿中足蛋白表达与痣样基底细胞癌综合征相关或不相关

背景：Podoplanin 是一种跨膜糖蛋白，在各种正常或肿瘤细胞上表达。有研究表明，podoplanin促进肿瘤细胞的迁移和侵袭。本研究评估了与痣样基底细胞癌综合征 (NBCCS) 相关或不相关的牙源性角化囊肿 (OKs) 和正角化牙源性囊肿 (OOC) 中的足蛋白表达。材料和方法：本研究共获得 50 个病灶，28 个 OK，18 个与 NBCCS 相关的 OK，4 个 OOC。使用以下评分评估上皮细胞中足蛋白的免疫组织化学表达：（a）免疫染色强度：（0：不存在，1：弱，2：中等，3：强，4：非常强）和（b）免疫染色的数量阳性细胞 (0: 0%, 1: <25%, 2: 25% to 50%, 3: 50% to 75%, and 4: >75%)。最终分数由 a 和 b 的分数相加确定，范围从 0 到 8（0：不存在，1 到 4：弱，5 到 8：强）。结果：在基底层 OKs 和 NBCCS 病变中，Podoplanin 表达明显更强。此外，在 NBCCS 病变的基底上层中，podoplanin 表达最高，其次是 OK 和 OOC 病变的基底上层。结论：Podoplanin在不同生物学行为的病灶中表达不同。Podoplanin 似乎在细胞增殖和迁移中起作用。其次是OK和OOC病变的基底上层。结论：Podoplanin在不同生物学行为的病灶中表达不同。Podoplanin 似乎在细胞增殖和迁移中起作用。其次是OK和OOC病变的基底上层。结论：Podoplanin在不同生物学行为的病灶中表达不同。Podoplanin 似乎在细胞增殖和迁移中起作用。